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Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies |
| Thua-Phong Lam1,2, Ngoc-Vi Nguyen Tran1,2, Long-Hung Dinh Pham1,3, Nghia Vo-Trong Lai1, Bao-Tran Ngoc Dang1, Ngoc-Lam Nguyen Truong1, Song-Ky Nguyen-Vo1, Thuy-Linh Hoang4, Tan Thanh Mai1, Thanh-Dao Tran1 |
1. Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 700000, Ho Chi Minh City, Vietnam;
2. Faculty of Pharmacy, Uppsala University, 75105, Uppsala, Sweden;
3. Department of Chemistry, Imperial College London, London, W12 0BZ, UK;
4. California Northstate University College of Pharmacy, California, 95757, USA |
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Abstract Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α-glucosidase and α-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC50 values of purified flavonoids on α-amylase and α-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both α-glucosidase and α-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure–activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA.
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| Keywords
Systematic review
Flavonoids
Dual-target
Glucosidase
Amylase
PRISMA
SAR
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| Fund:This research is funded by the University of Medicine and Pharmacy at Ho Chi Minh City under grant number 162/2019/HĐ-ĐHYD for Thanh-Dao Tran. The funding organization does not affect the transparency and the findings of the review. We would like to thank Phuc Quang Vu (School of Global Public Health, New York University) for the aid with numerical data processing and presentation and Lam-Duy Pham (Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City) for the aid with manuscript formatting. |
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Corresponding Authors:
Tan Thanh Mai,E-mail:mthtan@ump.edu.vn;Thanh-Dao Tran,E-mail:daott@ump.edu.vn
E-mail: mthtan@ump.edu.vn;daott@ump.edu.vn
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Issue Date: 19 February 2024
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