| Original Article |
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α-Glucosidase inhibitive diarylheptanoids from Ottelia acuminata var. acuminata, a traditional vegetable of Bai Nationality in Yunnan |
| Hong-Xing Liu1,2, Jun-Zeng Ma1, Yan-Song Ye1, Jian-Jun Zhao1, Shi-Jie Wan1, Xin-Yue Hu1,2, Gang Xu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2. University of Chinese Academy of Sciences, Beijing, 100049, China |
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Abstract Diabetes is an urgent health issue characterized by ethnic and regional variations, and is inseparable from the different dietary habits. It is worthy to note that the incidence of diabetes in Bai nationality has been reported to be much lower than Han in China. As a daily vegetable of Bai, the phytochemical and antidiabetic study of Ottelia acuminata var. acuminata had not been carried out. In this study, 41 metabolites with diverse diarylheptanoid (six new ones, Otteacumienes A-F), flavone, sesquiterpenoid, coumarin, lignan, polyacetylene, and alkaloid skeletons were characterized from O. acuminata var. acuminata. Among them, the racemic nature of 3 was characterized by chiral resolution and calculated ECD methods. The biological study revealed diarylheptanoids showed significant α-glucosidase inhibitory activities with 5 as the most effective one (60-fold stronger than acarbose). Molecular docking studies indicated that these structures have different binding cavities with acarbose. This study demonstrated that O. acuminata var. acuminata might correlated with the low incidence diabetes of Bai and the diarylheptanoids may have potential therapeutic value for diabetes mellitus.
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| Keywords
Ottelia acuminata var. acuminata
Bai nationality
Vegetable
Diarylheptanoids
α-glucosidase
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| Fund:This study was supported financially by the Second Tibetan Plateau Scientific Expedition and Research program (2019QZKK0502) and State Key Laboratory of Phytochemistry and Plant Resources in West China (E0230211Z1 and P2019-ZZ05). |
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Corresponding Authors:
Gang Xu,E-mail:xugang008@mail.kib.ac.cn
E-mail: xugang008@mail.kib.ac.cn
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Issue Date: 12 August 2022
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