A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of <i>Sarcandra glabra</i>

doi:10.1007/s13659-023-00418-8

Natural Products and Bioprospecting

2023, Vol. 13

Issue (6) : 53-53 DOI: 10.1007/s13659-023-00418-8

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A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

Jin-Ning Chu¹, Premanand Krishnan², Kuan-Hon Lim¹

1. School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia;
2. Foundation in Science, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia

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Abstract Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, S. glabra has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of S. glabra have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of S. glabra’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids.

Keywords Sarcandra glabra CaoShanHu Traditional Chinese medicine Lindenane-type sesquiterpenoids Biosynthetic pathway Biological activities

Fund:We thank REM Corporation Sdn. Bhd. (Dr Donald Chen) for inspiration and financial support.

Corresponding Authors: Kuan-Hon Lim,E-mail:KuanHon.Lim@nottingham.edu.my E-mail: KuanHon.Lim@nottingham.edu.my

Issue Date: 26 December 2023

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Jin-Ning Chu,Premanand Krishnan,Kuan-Hon Lim. A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra[J]. Natural Products and Bioprospecting, 2023, 13(6): 53-53.

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http://npb.kib.ac.cn/EN/10.1007/s13659-023-00418-8 OR http://npb.kib.ac.cn/EN/Y2023/V13/I6/53

[1]	Forest Research Institute Malaysia (FRIM). Flora of Malaysia i-Newsletter Part 3. 2013:1969-1969. https://www.mybis.gov.my/art/1985. Accessed 21 Dec 2022.<br />
[2]	He RR, Wang M, Li YF, Dai Y, Duan YH, Yao XS, et al. Effects of <i>Sarcandra glabra</i> extract on immune activity in restraint stress mice. Zhongguo Zhongyao Zazhi. 2009;34:100-3.<br />
[3]	Liu CP, Liu JX, Gu JY, Liu F, Li JH, Yang B, et al. Combination effect of three main constituents from <i>Sarcandra glabra</i> inhibits oxidative stress in the mice following acute lung injury: a role of MAPK-NF-κB pathway. Front Pharmacol. 2021;11:2082. https://doi.org/10.3389/fphar.2020.580064.<br />
[4]	Yang XR, Tanaka N, Tsuji D, Lu FL, Yan XJ, Itoh K, et al. Sarcaglabrin A, a conjugate of C15 and C10 terpenes from the aerial parts of <i>Sarcandra glabra</i>. Tetrahedron Lett. 2020;61: 151916. https://doi.org/10.1016/j.tetlet.2020.151916.<br />
[5]	Zeng YL, Liu JY, Zhang Q, Qin XH, Li ZL, Sun GJ, et al. The traditional uses, phytochemistry and pharmacology of <i>Sarcandra glabra</i> (Thunb.) Nakai, a Chinese herb with potential for development: review. Front Pharmacol. 2021;12:652926. https://doi.org/10.3389/fphar.2021.652926.<br />
[6]	Chloranthaceae VB. Flora Malesiana—series 1. Spermatophyta. 1984;10:123-44.<br />
[7]	Verdcourt B. Notes on Malesian Chloranthaceae. Kew Bull. 1985;40:213-24. https://doi.org/10.2307/4108497.<br />
[8]	Vossen HAM, Wessel M, editors. Plant resources of South-East Asia, No 16, Stimulants. Leiden: Backhuys Publishers; 1999. https://doi.org/10.2307/4118801.<br />
[9]	Swamy BGL, Bailey IW. <i>Sarcandra</i>, A vesselless genus of the <i>Chloranthaceae</i>. J Arnold Arbor. 1950;31:128.<br />
[10]	Zhou B, Liu KY, Chang J, Cheng CQ. Advances on chemical constituents and pharmacological activities of <i>Sarcandra glabra</i>. Chin J Mod Appl Pharm. 2009;6:982-6.<br />
[11]	Zhang H, Zhao P, Zhang YY, Huang XX, Song SJ. Chemical constituents and pharmacological properties of <i>Sarcandra glabra</i> (Thunb.) Nakai. Asian J Trad Med. 2019;14:237-46.<br />
[12]	Ludwiczuk A, Skalicka-Wo?niak K, Georgiev MI. Terpenoids. In: Badal S, Delgoda RBT, editors. Pharmacognosy: fundamentals. Applications and Strategy, Boston: Academic Press; 2017. p. 233-66. https://doi.org/10.1016/B978-0-12-802104-0.00011-1.<br />
[13]	Cocker W, McMurry TBH. Stereochemical relationships in the eudesmane (selinane) group of sesquiterpenes. Tetrahedron. 1960;8:181-204. https://doi.org/10.1016/0040-4020(60)80028-2.<br />
[14]	Li Y, Zhang DM, Li JB, Yu SS, Li Y, Luo YM. Hepatoprotective sesquiterpene glycosides from <i>Sarcandra glabra</i>. J Nat Prod. 2006;69:616-20. https://doi.org/10.1021/np050480d.<br />
[15]	Zhu LP, Li Y, Yang JZ, Zuo L, Zhang DM. Two new sesquiterpene lactones from <i>Sarcandra glabra</i>. J Asian Nat Prod Res. 2008;10:541-5. https://doi.org/10.1080/10286020801966773.<br />
[16]	Hu XR, Yang JS, Xu XD. Three novel sesquiterpene glycosides of <i>Sarcandra glabra</i>. Chem Pharm Bull. 2009;57:418-20. https://doi.org/10.1248/cpb.57.418.<br />
[17]	He XF, Yin S, Ji YC, Su ZS, Geng MY, Yue JM. Sesquiterpenes and dimeric sesquiterpenoids from <i>Sarcandra glabra</i>. J Nat Prod. 2010;73:45-50. https://doi.org/10.1021/np9006469.<br />
[18]	Teng F, Zhong HM, Chen CX, Liu HY. Four new eudesmane sesquiterpenoid lactones from <i>Chloranthus serratus</i>. Helv Chim Acta. 2009;92:1298-303. https://doi.org/10.1002/hlca.200800450.<br />
[19]	Do TO, Pham TK, Hang NTB, Pham HY, Tran HH, Nguyen XC, et al. Two new sesquiterpenes from <i>Sarcandra glabra</i>. Nat Prod Commun. 2010;5:1717-20.<br />
[20]	Wang C, Li Y, Li CJ, Yu SS, Zhang DM. Three new compounds from <i>Sarcandra glabra</i>. Chinese Chem Lett. 2012;23:823-6. https://doi.org/10.1016/j.cclet.2012.05.007.<br />
[21]	Hu XR, Wu HF, Zhang XP, Yang JS, Dai Z, Lin RC, et al. A new sesquiterpene lactone from <i>Sarcandra glabra</i>. Nat Prod Res. 2013;27:1197-201. https://doi.org/10.1080/14786419.2012.722084.<br />
[22]	Ni G, Zhang H, Liu HC, Yang SP, Geng MY, Yue JM. Cytotoxic sesquiterpenoids from <i>Sarcandra glabra</i>. Tetrahedron. 2013;69:564-9. https://doi.org/10.1016/j.tet.2012.11.023.<br />
[23]	Yaermaimaiti S, Wang P, Luo J, Li RJ, Kong LY. Sesquiterpenoids from the seeds of <i>Sarcandra glabra</i> and the potential anti-inflammatory effects. Fitoterapia. 2016;111:7-11. https://doi.org/10.1016/j.fitote.2016.03.020.<br />
[24]	Li YT, Li SF, Lei C, You JQ, Huang JC, Hou AJ. Dimeric sesquiterpenoids and anti-inflammatory constituents of <i>Sarcandra glabra</i>. Bioorg Chem. 2022;124: 105821. https://doi.org/10.1016/j.bioorg.2022.105821.<br />
[25]	Wang YY, Li QR, Chi J, Li JX, Kong LY, Luo J. Sesquiterpenoids from the leaves of <i>Sarcandra glabra</i>. Chin J Nat Med. 2022;20:215-20. https://doi.org/10.1016/S1875-5364(21)60102-4.<br />
[26]	Takeda Y, Yamashita H, Matsumoto T, Terao H, Chloranthalactone F. A sesquiterpenoid from the leaves of <i>Chloranthus glaber</i>. Phytochemistry. 1993;33:713-5. https://doi.org/10.1016/0031-9422(93)85480-F.<br />
[27]	Wong KC, Tan MS, Ali DMH, Teoh SG, Osman H, Tan SK. Essential oil of the leaves of <i>Sarcandra glabra</i> (Thunb.) Nakai. J Essent Oil Res. 2009;21:71-3. https://doi.org/10.1080/10412905.2009.9700114.<br />
[28]	Yue GZ, Yang L, Yuan CC, Du B, Liu B. Progress in total syntheses of lindenane-type sesquiterpenoids and their dimers. Chin J Org Chem. 2013;33:90-100. https://doi.org/10.6023/cjoc201207003.<br />
[29]	Liao SG, Yue JM. Dimeric sesquiterpenoids. In: Kinghorn AD, Falk H, Gibbons S, Kobayashi J, editors. Prog Chem Org Nat Prod, vol. 101. Cham: Springer International Publishing; 2016. p. 1-112. https://doi.org/10.1007/978-3-319-22692-7_1.<br />
[30]	Uchida M, Kusano G, Kondo Y, Takemoto T, Nozoe S. Two new sesquiterpenoids from <i>Chloranthus glaber</i> Makino. Heterocycles. 1978;9:139-44. https://doi.org/10.3987/r-1978-02-0139.<br />
[31]	Okamura H, Nakashima N, Iwagawa T, Nakayama N, Nakatani M. The structures of two lindenane sesquiterpene glucosides from <i>Chloranthus glaber</i>. Chem Lett. 1994;23:1541-2. https://doi.org/10.1246/cl.1994.1541.<br />
[32]	Tsui WY, Brown GD. Cycloeudesmanolides from <i>Sarcandra glabra</i>. Phytochemistry. 1996;43:819-21. https://doi.org/10.1016/0031-9422(96)00352-4.<br />
[33]	Chi J, Wei SS, Gao HL, Xu DQ, Zhang LN, Yang L, et al. Diverse chemosensitizing 8,9-secolindenane-type sesquiterpenoid oligomers and monomers from <i>Sarcandra glabra</i>. J Org Chem. 2019;84:9117-26. https://doi.org/10.1021/acs.joc.9b00986.<br />
[34]	Wang C, Zhu LP, Yang JZ, Li CJ, Zhang DM. Chemical constituents from <i>Sarcandra glabra</i>. China J Chin Mater Medicaedica. 2010;35:714-7. https://doi.org/10.4268/cjcmm20100612.<br />
[35]	Li X, Zhang YF, Yang L, Feng Y, Liu YM, Zeng X. Sesquiterpenoids from the whole plant of <i>Sarcandra glabra</i>. Yaoxue Xuebao. 2011;46:1349-51.<br />
[36]	Zheng XF, Liu HY, Zhong HM. Chemical constituents from <i>Sarcandra glabra</i>. Nat Prod Res Dev. 2014;26:1221-4.<br />
[37]	Wang P, Luo J, Zhang YM, Kong LY. Sesquiterpene dimers esterified with diverse small organic acids from the seeds of <i>Sarcandra glabra</i>. Tetrahedron. 2015;71:5362-70. https://doi.org/10.1016/j.tet.2015.05.112.<br />
[38]	Wang P, Li RJ, Liu RH, Jian KL, Yang MH, Yang L, et al. Sarglaperoxides A and B, sesquiterpene-normonoterpene conjugates with a peroxide bridge from the seeds of <i>Sarcandra glabra</i>. Org Lett. 2016;18:832-5. https://doi.org/10.1021/acs.orglett.6b00112.<br />
[39]	Wang YY, Cui ZR, Chi J, Tang PF, Zhang MH, Li JX, et al. Sarcaglarols A-D, lindenane-monoterpene heterodimers from <i>Sarcandra glabra</i> based on molecular networks. Chin J Chem. 2021;39:129-36. https://doi.org/10.1002/cjoc.202000456.<br />
[40]	Sun YP, Wang YY, Li YQ, Wang SY, Zhang DY, Kong LY, et al. Sarcaglarone A, a lindenane-monoterpene heterodimer from the seeds of <i>Sarcandra glabra</i>. Org Biomol Chem. 2022;20:9222-7. https://doi.org/10.1039/d2ob01830f.<br />
[41]	Sun YP, Chi J, Zhang LJ, Wang SY, Chen ZH, Zhang H, et al. Sarglaromatics A-E: a class of naphthalene-like architecture fused norlindenane sesquiterpene dimers from <i>Sarcandra glabra</i>. J Org Chem. 2022;87:4323-32. https://doi.org/10.1021/acs.joc.2c00014.<br />
[42]	Xiao LG, Li P, Yan H, Ni W, He L, Liu HY. Sarcanolides C-E: Three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from <i>Sarcandra glabra</i>. Org Biomol Chem. 2022;20:1320-6. https://doi.org/10.1039/d1ob02417e.<br />
[43]	Wang YY, Chen ZH, Li QR, Cui LT, Chi J, Li JX, et al. Sarglafuran A, a lindenane-type sesquiterpene dimers with unique furan ring from the leaves of <i>Sarcandra glabra</i>. Tetrahedron Lett. 2022;98: 153834. https://doi.org/10.1016/j.tetlet.2022.153834.<br />
[44]	Zhou B, Zimbres FM, Butler JH, Xu CH, Haney RS, Wu Y, et al. Picomolar antimalarial agent from a Chinese medicinal plant. Sci China Chem. 2022;65:82-6. https://doi.org/10.1007/s11426-021-1124-x.<br />
[45]	Cui ZR, Wang YY, Li JX, Chi J, Zhang PP, Kong LY, et al. Natural and pseudonatural lindenane heterodimers from <i>Sarcandra glabra</i> by molecular networking. Org Lett. 2022;24:9107-11. https://doi.org/10.1021/acs.orglett.2c03769.<br />
[46]	Luo YM. Study on Jiangxi characteristic Chinese medicinal materials <i>Sarcandra glabra</i> and Cinnamomum Camphora. China Academy of Chinese Medical Sciences, 2004.<br />
[47]	He XF, Zhang S, Zhu RX, Yang SP, Yuan T, Yue JM. Sarcanolides A and B: two sesquiterpenoid dimers with a nonacyclic scaffold from <i>Sarcandra hainanensis</i>. Tetrahedron. 2011;67:3170-4. https://doi.org/10.1016/j.tet.2011.03.021.<br />
[48]	Wei SS, Chi J, Zhou MM, Li RJ, Li YR, Luo J, et al. Anti-inflammatory lindenane sesquiterpeniods and dimers from <i>Sarcandra glabra</i> and its upregulating AKT/Nrf2/HO-1 signaling mechanism. Ind Crops Prod. 2019;137:367-76. https://doi.org/10.1016/j.indcrop.2019.05.041.<br />
[49]	Bai M, Liu YY, Li YL, Shi WY, Li KX, Lu LW, et al. Meroterpenoids and sesquiterpene dimers from <i>Sarcandra glabra</i> with anti-neuroinflammatory activity. Ind Crops Prod. 2022;183: 114983. https://doi.org/10.1016/j.indcrop.2022.114983.<br />
[50]	Tao R, Tang PF, Gao JJ, Li JX, Sun YP, Luo J, et al. The anti-inflammatory activity by suppressing the TRAF6/MAPKs pathway of trishizukaol A from <i>Sarcandra glabra</i>. Phytomedicine. 2022;98: 153952. https://doi.org/10.1016/j.phymed.2022.153952.<br />
[51]	Banik BK, Tiwari A, Sahoo BM. Sesquiterpenes: a chemical synthesis and biological activity. Terpenoids, 2022, p. 487-516. https://doi.org/10.1201/9781003008682-15.<br />
[52]	Tashkhodzhaev B, Abduazimov BK. Stereochemistry of sesquiterpenes of the germacrane type. Chem Nat Compd. 1997;33:382-8. https://doi.org/10.1007/BF02282357.<br />
[53]	Luo YM, Liu AH, Yu BW, Kang LJ, Huang LQ. Studies on chemical constituents of <i>Sarcandra glabra</i>. Chin Pharm J. 2005;40:1296-8. https://doi.org/10.3321/j.issn:1001-2494.2005.17.005.<br />
[54]	Harrowven DC, Pattenden G. Transannular electrophilic cyclizations. In: Trost BM, Fleming IBT, editors. Comprehensive organic synthesis. Oxford: Pergamon; 1991. p. 379-411. https://doi.org/10.1016/b978-0-08-052349-1.00067-6.<br />
[55]	Wang AQ, Feng SC, He X, Xu RS. A new sesquiterpene lactone from <i>Sarcandra glabra</i>. Acta Pharm Sin. 1988;23:64-6.<br />
[56]	Zeng AH, Luo YM, Liu N. Determination of istanbulin A in <i>Sarcandra glabra</i>. J Chinese Med Mater. 2006;29:443-4.<br />
[57]	Durán-Pe?a MJ, Botubol Ares JM, Hanson JR, Collado IG, Hernández-Galán R. Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit. Nat Prod Rep. 2015;32:1236-48. https://doi.org/10.1039/c5np00024f.<br />
[58]	Chen ZH, Sun YP, Wang YY, Kong LY, Luo J. Two new sesquiterpenoids from the roots of <i>Sarcandra glabra</i>. Nat Prod Res. 2022. https://doi.org/10.1080/14786419.2022.2089670.<br />
[59]	Li Y. Studies on the chemical constituents and bioactivities of <i>Sarcandra glabra</i>, <i>Cercis chinensis</i> and <i>Photinia parvifolia</i>. Chinese Academy of Medical Science and Perking Union Medical College, 2006.<br />
[60]	Karamenderes C, Bedir E, Pawar R, Baykan S, Khan IA. Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from <i>Centaurea hierapolitana</i>. Phytochemistry. 2007;68:609-15. https://doi.org/10.1016/j.phytochem.2006.10.013.<br />
[61]	Wu SX, Lv GY, Zhao LS, Chen SH, Zhou HK, Li QL. Determination of β-elemene in volatile oil of fresh <i>Sarcandra glabra</i> (Thunb.) Nakai by HPLC. Chin J Mod App Pharm. 2010;27:59-61.<br />
[62]	Sela F, Karapandzova M, Stefkov G, Cvetkovikj I, Trajkovska-Dokikj E, Kaftandzieva A, et al. Chemical composition and antimicrobial activity of berry essential oil of <i>Juniperus oxycedrus</i> L. (Cupressaceae) grown wild in Republic of Macedonia. Maced Pharm Bull. 2013;59:41-8.<br />
[63]	Li X, Zhang YF, Zeng X, Liu YM, Feng Y. Two new skeleton compounds from <i>Sarcandra glabra</i>. Helv Chim Acta. 2012;95:998-1002. https://doi.org/10.1002/hlca.201100352.<br />
[64]	Wu HF, Hu XR, Zhang XP, Chen SL, Yang JS, Xu XD. Isolation and chemotaxonomic significance of megastigmane-type sesquiterpenoids from <i>Sarcandra glabra</i>. J Med Plants Res. 2012;6:4501-4. https://doi.org/10.5897/jmpr12.532.<br />
[65]	Cox-Georgian D, Ramadoss N, Dona C, Basu C. Therapeutic and medicinal uses of terpenes. Med Plants from Farm to Pharm. 2019. https://doi.org/10.1007/978-3-030-31269-5_15.<br />
[66]	Ninkuu V, Zhang L, Yan J, Fu Z, Yang T, Zeng H. Biochemistry of terpenes and recent advances in plant protection. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22115710.<br />
[67]	Heskes AM, Sundram TCM, Boughton BA, Jensen NB, Hansen NL, Crocoll C, et al. Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 2018;93:943-58. https://doi.org/10.1111/tpj.13822.<br />
[68]	Kushiro T, Ebizuka Y. Triterpenes. In: Liu HW, Mander LBT, editors. Comprehensive Natural Products II: Chemistry and Biology, vol. 1, Oxford: Elsevier; 2010, p. 673-708. https://doi.org/10.1016/b978-008045382-8.00007-1.<br />
[69]	Luo YM, Liu AH, Zhang DM, Huang LQ. Two new triterpenoid saponins from <i>Sarcandra glabra</i>. J Asian Nat Prod Res. 2005;7:829-34. https://doi.org/10.1080/10286020410001721104.<br />
[70]	Fu JQ, Liang JY. Studies on the chemical constituents of <i>Sarcandra glabra</i>. Strait Pharm J. 2013;25:46-50.<br />
[71]	Cornforth JW. Terpenoid biosynthesis. Chem Br. 1968;4:102-6.<br />
[72]	Yang WQ, Hai P, Xiao H, Gao Y, Tao YH, Miao DR, et al. Glabralides A-C, three novel meroterpenoids from <i>Sarcandra glabra</i>. Tetrahedron. 2018;74:341-7. https://doi.org/10.1016/j.tet.2017.12.001.<br />
[73]	Zhou B, Gong Q, Fu Y, Zhou JS, Zhang HY, Yue JM. Sarglamides A-E, indolidinoid-monoterpenoid hybrids with anti-neuroinflammatory activity from a <i>Sarcandra</i> species. Org Lett. 2023;25:1464-9. https://doi.org/10.1021/acs.orglett.3c00196.<br />
[74]	Noel JP, Austin MB, Bomati EK. Structure-function relationships in plant phenylpropanoid biosynthesis. Curr Opin Plant Biol. 2005;8:249-53. https://doi.org/10.1016/j.pbi.2005.03.013.<br />
[75]	Vogt T. Phenylpropanoid biosynthesis. Mol Plant. 2010;3:2-20. https://doi.org/10.1093/mp/ssp106.<br />
[76]	Pedras MSC, Zheng Q. The chemistry of Arabidopsis thaliana. In: Liu HW, Mander LBT, editors. Comprehensive Natural Products II: Chemistry and Biology, vol. 3, Oxford: Elsevier; 2010, p. 1297-315. https://doi.org/10.1016/b978-008045382-8.00090-3.<br />
[77]	Das AB, Goud VV, Das C. Phenolic compounds as functional ingredients in beverages. In: Grumezescu AM, Holban AM, editors. Value-Added Ingredients and Enrichments of Beverages: Volume 14: The Science of Beverages, Academic Press; 2019, p. 285-323. https://doi.org/10.1016/B978-0-12-816687-1.00009-6.<br />
[78]	Feng SX, Xu LX, Wu M, Hao J, Qiu SX, Wei XY. A new coumarin from <i>Sarcandra glabra</i>. Fitoterapia. 2010;81:472-4. https://doi.org/10.1016/j.fitote.2009.12.009.<br />
[79]	Wu HF, Hu XR, Zhang XP, Chen SL, Yang JS, Xu XD. Benzyl 2-β-glucopyranosyloxybenzoate, a new phenolic acid glycoside from <i>Sarcandra glabra</i>. Molecules. 2012;17:5212-8. https://doi.org/10.3390/molecules17055212.<br />
[80]	Jin L, Ying ZH, Yu CH, Zhang HH, Yu WY, Wu XN. Isofraxidin ameliorated influenza viral inflammation in rodents via inhibiting platelet aggregation. Int Immunopharmacol. 2020;84: 106521. https://doi.org/10.1016/j.intimp.2020.106521.<br />
[81]	China Pharmacopoeia Commission. Pharmacopoeia of People’s Republic of China. vol. 1. Beijing SE: China Medical Science Press Beijing; 2010. LK—https://worldcat.org/title/901666820.<br />
[82]	Wang MJ, Zhao J, Zhao Y, Huang RY, Li G, Zeng X, et al. A new coumarin isolated from <i>Sarcandra glabra</i> as potential anti-inflammatory agent. Nat Prod Res. 2016;30:1796-801. https://doi.org/10.1080/14786419.2015.1079186.<br />
[83]	Du NN, Bai M, Zhang X, Zhou L, Huang XX, Song SJ. Coumarins from <i>Sarcandra glabra</i> (Thunb.) Nakai and acetylcholinesterase inhibiting activity. Chem Biodivers. 2022. https://doi.org/10.1002/cbdv.202200558.<br />
[84]	Huang MJ, Li YL, Zeng GY, Yuan W, Tan JB, Tan GS, et al. Chemical constituents of <i>Sarcandra glabra</i>. Cent South Pharm. 2007;5:459-61.<br />
[85]	Wang F, Yuan ST, Zhu DN. Active components of antitumor fraction from <i>Sarcandra glabra</i>. Chin J Nat Med. 2007;5:174-8.<br />
[86]	Xu XD, Hu XR, Yuan JQ, Yang JS. Studies on chemical constituents of <i>Sarcandra glabra</i>. Zhongguo Zhongyao Zazhi. 2008;33:900-2. https://doi.org/10.2991/icimm-15.2015.43.<br />
[87]	Yuan K, Zhu JX, Si JP, Cai HK, Ding XD, Pan YJ. Studies on chemical constituents and antibacterial activity from n-butanol extract of <i>Sarcandra glabra</i>. Zhongguo Zhongyao Zazhi. 2008;33:1843-6.<br />
[88]	Zhu L, Li Y, Yang J, Zuo L, Zhang D. Studies on chemical constituents of <i>Sarcandra glabra</i>. China J Chin Mater Medicaedica. 2008;33:155-7.<br />
[89]	Li X, Zhang YF, Zeng X, Yang L, Deng YH. Chemical profiling of bioactive constituents in <i>Sarcandra glabr</i>a and its preparations using ultra-high-pressure liquid chromatography coupled with LTQ orbitrap mass spectrometry. Rapid Commun Mass Spectrom. 2011;25:2439-47. https://doi.org/10.1002/rcm.5123.<br />
[90]	Luo YM, Lin FX, Du YQ, Li HT, Jiang CX, Liu H. Studies on the chemical constituents of <i>Sarcandra glabra</i>. Proceedings of the 5th international conference on information engineering for mechanics and materials, Advances in engineering research, Atlantis Press; 2015, p. 226-9. https://doi.org/10.2991/icimm-15.2015.43.<br />
[91]	Zále?ák F, Bon DJYD, Pospí?il J. Lignans and Neolignans: plant secondary metabolites as a reservoir of biologically active substances. Pharmacol Res. 2019;146: 104284. https://doi.org/10.1016/j.phrs.2019.104284.<br />
[92]	Liu J, Wen QY, Tian HR, Zhan BJF, Zhu LP, Yang DP, et al. (±)-Sarcanan A, a pair of new enantiomeric dihydrobenzofuran neolignans from the aerial parts of <i>Sarcandra glabra</i>. Nat Prod Res. 2022;37:2480-5. https://doi.org/10.1080/14786419.2022.2050229.<br />
[93]	Zhu XQ, Jiang YL, Zheng Q, Zhang AP, Shi L, Xia LM, et al. Apoptosis of platelets inhibited by Herba Sarcandrae extract through the mitochondria pathway. Evid-Based Complement Altern Med. 2018;2018:1956902. https://doi.org/10.1155/2018/1956902.<br />
[94]	Lu XN, Sun HJ, Zhu J, Hu XY, Yan XJ, Shang GB. Effects of flavonoids from <i>Sarcandrae glabra</i> on differentiation and maturation of megakaryocytes in cell co-culture system. Trad Chin Med Clin Pharmacol. 2019;30:1277-83.<br />
[95]	Mutha RE, Tatiya AU, Surana SJ. Flavonoids as natural phenolic compounds and their role in therapeutics: an overview. Futur J Pharm Sci. 2021;7:25. https://doi.org/10.1186/s43094-020-00161-8.<br />
[96]	Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5: e47. https://doi.org/10.1017/jns.2016.41.<br />
[97]	Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2:1231-46. https://doi.org/10.3390/nu2121231.<br />
[98]	Liu X, Yang J, Fu J, Xu PL, Xie TG, Bai LP, et al. Monoterpene-flavonoid conjugates from <i>Sarcandra glabra</i> and their autophagy modulating activities. Bioorg Chem. 2021;112: 104830. https://doi.org/10.1016/j.bioorg.2021.104830.<br />
[99]	Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res. 2017;61:1361779. https://doi.org/10.1080/16546628.2017.1361779.<br />
[100]	Ishikura N. Pelargonidin glycosides in fruits. Experientia. 1971;27:1006. https://doi.org/10.1007/BF02138844.<br />
[101]	Li Y, Zhang DM, Yu SS, Li JB, Luo YM. A novel phenylpropanoid-substituted catechin glycoside and a new dihydrochalcone from <i>Sarcandra glabra</i>. Chin Chem Lett. 2006;17:207-10.<br />
[102]	Zou X, Gao H, Wu B, Wang Y, Wang S, Yang S. Study on the chemical constituents of <i>Sarcandra glabra</i>. Chin Trad Herb Drugs. 2007;38:354-6.<br />
[103]	Cao CM, Xu LJ, Chen K, Peng Y, Xiao PG. Chemical study on petroleum ether portion of <i>Sarcandra hainanensis</i>. Zhongguo Zhongyao Zazhi. 2009;34:1009-10.<br />
[104]	Zheng YB, Xu XP, Zou XW, Guan LS, Zhang DY, Liu J, et al. Chemical constituents with the antioxidant activity in <i>Sarcandra glabra</i>. J Fujian Norm Univ Nat Sci Ed. 2016;32:98-102.<br />
[105]	Spiegel M, Andruniów T, Sroka Z. Flavones’ and flavonols’ antiradical structure-activity relationship—a quantum chemical study. Antioxidants. 2020. https://doi.org/10.3390/antiox9060461.<br />
[106]	Qin YQ, Liu W, Yin R, Xiao PT, Wang ZY, Huang TQ, et al. New 4’,5’-methylenedioxyflavone derivatives from the whole plant of <i>Sarcandra glabra</i>. Nat Prod Res. 2022. https://doi.org/10.1080/14786419.2022.2111562.<br />
[107]	Li Y, Yao JY, Han CY, Yang JX, Chaudhry MT, Wang S, et al. Quercetin, inflammation and immunity. Nutrients. 2016. https://doi.org/10.3390/nu8030167.<br />
[108]	Calderon-Montano JM, Burgos-Moron E, Perez-Guerrero C, Lopez-Lazaro M. A review on the dietary flavonoid kaempferol. Mini-Rev Med Chem. 2011;11:298-344. https://doi.org/10.2174/138955711795305335.<br />
[109]	Huang MJ, Zeng GY, Tan JB, Li YL, Tan GS, Zhou YJ. Studies on flavonoid glycosides of <i>Sarcandra glabra</i>. Zhongguo Zhongyao Zazhi. 2008;33:1700-2.<br />
[110]	Tong SQ, Huang J, Wang LB. Studies on the chemical constituents of <i>Sarcandra glabra</i>. Zhongcaoyao. 2010;41:198-201.<br />
[111]	Cao CM, Xu LJ, Peng Y, Shi QW, Xiao PG. Two new flavan-flavanones from <i>Sarcandra hainanensis</i>. Chem Pharm Bull. 2010;58:1395-8. https://doi.org/10.1248/cpb.58.1395.<br />
[112]	Duodu KG, Awika JM. Phytochemical-related health-promoting attributes of sorghum and millets. In: Taylor JRN, Duodu K, editors. Sorghum and millets: chemistry technology, and nutritional attributes. AACC International Press; 2018. p. 225-58. https://doi.org/10.1016/B978-0-12-811527-5.00008-3.<br />
[113]	Bodduluru LN, Kasala ER, Madhana RM, Barua CC, Hussain MI, Haloi P, et al. Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA . Int Immunopharmacol. 2016;30:102-10. https://doi.org/10.1016/j.intimp.2015.11.036.<br />
[114]	Zhou H, Liang JL, Lv D, Hu YF, Zhu Y, Si J, et al. Characterization of phenolics of <i>Sarcandra glabra</i> by non-targeted high-performance liquid chromatography fingerprinting and following targeted electrospray ionisation tandem mass spectrometry/time-of-flight mass spectrometry analyses. Food Chem. 2013;138:2390-8. https://doi.org/10.1016/j.foodchem.2012.12.027.<br />
[115]	Bernatoniene J, Kopustinskiene DM. The role of catechins in cellular responses to oxidative stress. Molecules. 2018. https://doi.org/10.3390/molecules23040965.<br />
[116]	Cao CM, Peng Y, Xu LJ, Wang YJ, Yang JS, Xiao PG. Two flavonoid dimers from <i>Sarcandra hainanensis</i> (Pei) Swamy et Bailey. Chem Pharm Bull. 2009;57:743-6. https://doi.org/10.1248/cpb.57.743.<br />
[117]	Yadav AN, Kour D, Rana KL, Yadav N, Singh B, Chauhan VS, et al. Chapter 20—Metabolic engineering to synthetic biology of secondary metabolites production. In: Gupta VK, Pandey AB, editors, Amsterdam: Elsevier; 2019, p. 279-320. https://doi.org/10.1016/B978-0-444-63504-4.00020-7.<br />

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