Progress on the Chemical Constituents Derived from Glucosinolates in Maca (<i>Lepidium meyenii</i>)

doi:10.1007/s13659-018-0185-7

Natural Products and Bioprospecting

2018, Vol. 8

Issue (6) : 405-412 DOI: 10.1007/s13659-018-0185-7

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Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

Yan-Jie Huang^1,2,3, Xing-Rong Peng^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before. Recently, a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca. This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway, which indicates that macamides, thiohydantoins, and some alkaloids may originate from glucosinolates. Interestingly, thiohydantoins from Maca are the first type of thiohydantoin derivatives to be found from a natural source and may contribute to some significant effects of Maca.

Keywords Maca (Lepidium meyenii Walp.) Chemical constituents Thiohydantoins Biosynthetic pathway

Fund:This research work was financially supported by NSFC project and YiKe R&D Project (KIB-20140708Q), as well as Foundation of Key Laboratory of Tobacco Chemistry of Yunnan Province (KCFZ-2017-1096) and Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ14).

Corresponding Authors: Ming-Hua Qiu E-mail: mhchiu@mail.kib.ac.cn

Issue Date: 21 November 2018

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Yan-Jie Huang,Xing-Rong Peng,Ming-Hua Qiu. Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)[J]. Natural Products and Bioprospecting, 2018, 8(6): 405-412.

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http://npb.kib.ac.cn/EN/10.1007/s13659-018-0185-7 OR http://npb.kib.ac.cn/EN/Y2018/V8/I6/405

1. S. Beharry, M. Heinrich, J. Ethnopharmacol. 211, 126-170 (2018)
2. J.C. Shu, H.Q. Cui, Y.Z. Huang, X.Y. Huang, M. Yang, Chin. J. Chin. Mater. Med. 40, 4536-4540 (2015)
3. C. Zhang, J.F. Ma, F.H. Ge, R.M. Yu, J. Chin. Med. Mater. 39, 2668-2674 (2016)
4. M. Xu, Z.J. Wang, S.J. Yang, H. Song, L. Xu, Q. Ma, C.R. Yang, Food Res. Dev. 38, 193-199 (2017)
5. Y. Wang, Y. Wang, B. Mcneil, L.M. Harvey, Food Res. Int. 40, 783-792 (2007)
6. A. Buchynskyy, J.R. Gillespie, Z.M. Herbst, R.M. Ranade, F.S. Buckner, M.H. Gelb, Med. Chem. Lett. 8, 886-891 (2017)
7. S. Poyraz, S. Belveren, M. Ülger, E. Şahin, H.A. Döndaş, Mon. Chem. 148, 2173-2182 (2017)
8. M. Zuo, X. Xu, Z. Xie, R. Ge, Z. Zhang, Z. Li, J. Bian, Eur. J. Med. Chem. 125, 1002-1022 (2017)
9. M. Bassetto, S. Ferla, F. Pertusati, S. Kandil, A.D. Westwell, A. Brancale, C. Mcguigan, Eur. J. Med. Chem. 118, 230-243 (2016)
10. J.W. Fahey, A.T. Zalcmann, P. Talalay, Phytochemistry 56, 5-51 (2001)
11. G. Li, U. Ammermann, C.F. Quirós, Econ. Bot. 55, 255-262 (2001)
12. E. Yábar, R. Pedreschi, R. Chirinos, D. Campos, Food Chem. 127, 1576-1583 (2011)
13. Q. Deng, K.G. Zinoviadou, C.M. Galanakis, V. Orlien, N. Grimi, E. Vorobiev, N. Lebovka, F.J. Baeba, Food Eng. Rev. 7, 357-381 (2015)
14. M. Ikeuchi, T. Koyama, S. Takei, T. Kino, K. Yazawa, J. Health Sci. 55, 178-182 (2009)
15. U. Wittstock, N. Agerbirk, E.J. Stauber, C.E. Olsen, M. Hippler, T. Mitchell-Olds, J. Gershenzon, H. Vogel, PNAS 101, 4859-4864 (2004)
16. E. Esparza, A. Hadzich, W. Kofer, A. Mithöfer, E.G. Cosio, Phytochemistry 116, 138-148 (2015)
17. I. Muhammad, J. Zhao, D.C. Dunbar, I.A. Khan, Phytochemistry 59, 105-110 (2002)
18. J. Zhao, I. Muhammad, D.C. Dunbar, J. Mustafa, I.A. Khan, J. Agric. Food Chem. 53, 690-693 (2005)
19. Z. Hajdu, S. Nicolussi, M. Rau, L. Lorántfy, P. Forgo, J. Hohmann, D. Csupor, J. Gertsch, J. Nat. Prod. 77, 1663-1669 (2014)
20. X. Chen, J. Chen, J.L. Deng, Y.Q. Zhu, W.Y. Li, B. Jie, T.Y. Chen, Phytochem. Lett. 25, 65-69 (2018)
21. F.E. Chain, A. Grau, J.C. Martins, C.A.N. Catalán, Phytochem. Lett. 8, 145-148 (2014)
22. L. Lin, J. Huang, D. Sun-Waterhouse, M. Zhao, K. Zhao, J. Que, Int. J. Food Sci. Technol. 53, 304-312 (2018)
23. M.M. Mccollom, J.R. Villinski, K.L. Mcphail, L.E. Craker, S. Gafner, Phytochem. Anal. 16, 463-469 (2005)
24. J.J. Chen, P.F. Gong, Y.L. Liu, B.Y. Liu, D. Eggert, Y.H. Guo, M.X. Zhao, Q.S. Zhao, B. Zhao, J. Food Sci. 83, 966-974 (2018)
25. J. Chen, Q. Zhao, Y. Liu, P. Gong, L. Cao, X. Wang, B. Zhao, Int. J. Food Prop. 20, 3112-3123 (2017)
26. H. Wu, C.J. Kelley, A. Pino-Figueroa, H.D. Vu, T.J. Maher, Bioorg. Med. Chem. 21, 5188-5197 (2013)
27. H. Almukadi, H. Wu, M. Böhlke, C.J. Kelley, T.J. Maher, A. Pino-Figueroa, Mol. Neurobil. 48, 333-339 (2013)
28. M.Y. Yu, X.J. Qin, X.R. Peng, X. Wang, X.X. Tian, Z.R. Li, M.H. Qin, Tetrahedron 73, 4392-4397 (2017)
29. M. Zhou, H.Y. Ma, Z.H. Liu, G.Y. Yang, G. Du, Y.Q. Ye, G.P. Li, Q.F. Hu, J. Agric. Food Chem. 65, 1887-1892 (2017)
30. M.Y. Yu, X.J. Qin, L.D. Shao, X.R. Peng, L. Li, H. Yang, M.H. Qiu, Tetrahedron Lett. 58, 1684-1686 (2017)
31. M. Zhou, H.Y. Ma, H.H. Xing, P. Li, G.P. Li, H.C. Geng, Q.F. Hu, G.Y. Yang, Org. Lett. 19, 4952-4955 (2017)
32. T. Mendgen, C. Steuer, C.D. Klein, J. Med. Chem. 55, 743-753 (2012)
33. J.E. Tompkins, J. Med. Chem. 29, 855-859 (1986)
34. A.M. Alobaid, H.I. Elsubbagh, A.I. Khodair, M.M. Elmazar, Anti-Cancer Drug. 7, 873-880 (1996)
35. A. Takahashi, H. Matsuoka, K. Yamada, Y. Uda, Food Chem. Toxicol. 43, 521-528 (2005)
36. J.V. Marx, D.A. Richert, W.W. Westerfeld, J. Med. Chem. 13, 1179-1181 (1970)
37. B. Cui, B.L. Zheng, K. He, Q.Y. Zheng, J. Nat. Prod. 66, 1101-1103 (2003)
38. W. Jin, X. Chen, P. Dai, L. Yu, Phytochem. Lett. 17, 158-161 (2016)
39. M. Zhou, R.Q. Zhang, Y.J. Chen, L.M. Liao, Y.Q. Sun, Z.H. Ma, Q.F. Yang, P. Li, Y.Q. Ye, Q.F. Hu, Phytochem. Lett. 23, 137-140 (2018)
40. S. Piacente, V. Carbone, A. Plaza, A. Zampelli, C. Pizza, J. Agric. Food Chem. 50, 5621-5625 (2002)
41. X.X. Tian, X.R. Peng, M.Y. Yu, Y.J. Huang, X. Wang, L. Zhou, M.H. Qiu, Phytochem. Lett. 25, 70-73 (2018)
42. Z. Zang, M.J. Li, Z. Lei, L. Ma, F.Y. Liu, D.L. Li, X.H. Wu, Y. Zhao, J. Chem. Soc. Pak. 38, 487-493 (2016)
43. H.C. Geng, D.S. Yang, X.L. Chen, L.X. Wang, M. Zhou, Phtochem. Lett. 26, 208-211 (2018)
44. T. Herraiz, C.S. Ough, J. Agric. Food Chem. 41, 959-964 (1993)

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