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Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus |
| Li Liu1,2, Jun-Jie Han1,2, Tian-Shun Xu3, Rui-Xing Liu1,2, Li Bao1, Hong-Wei Liu1,2 |
1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
2 Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 College of Life Sciences, Hebei University, Baoding 071002, China |
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Abstract Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.
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| Keywords
Lentinellus ursinus
Heptelidic acid derivatives
Biosynthetic pathway
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| Fund:This work was financially supported by the National Natural Science Foundation of China (21472233 and 81673334). |
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Corresponding Authors:
Hong-Wei Liu
E-mail: liuhw@im.ac.cn
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Issue Date: 19 September 2018
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