| ORIGINAL ARTICLES |
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Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity |
| Xin-Yu Jia1, Yong-Mei Wu2, Jing-Ya Li2, Chun Lei1, Ai-Jun Hou1 |
1 School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China;
2 National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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Abstract Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC50 value of 0.52±0.11 μM.
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| Keywords
Ficus hispida
Moraceae
Alkaloids
Antiinflammation
Nuclear factor-κB
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| Fund:Financial supports from the National Natural Science Foundation of China (Grant Nos. 81222045 and 21672040) and the Drug Innovation Major Project of China (Grant No. 2018ZX09735001-002-006) are gratefully acknowledged. |
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Corresponding Authors:
Chun Lei, Ai-Jun Hou
E-mail: chunlei@fudan.edu.cn;ajhou@shmu.edu.cn
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Issue Date: 29 February 2020
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1. Z. Zhou, M.G. Gilbert, Flora China 5, 37-71 (2003)
2. M. Shahriar, S. Islam, S. Parvin, S. Hoque, J. Sci. Res. 5, 393-397 (2013)
3. L.X. Zhang, Z.B. Guan, Subtrop. Plant Sci. 33, 60-62 (2004)
4. M.S.I. Howlader, M.A. Siraj, S.K. Dey, A. Hira, A. Ahmed, M.H. Hossain, Evid-Based Compl. Alt. 7390359 (2017)
5. P. Deepa, K. Sowndhararajan, S. Kim, S.J. Park, J. Ethnopharmacol. 215, 210-232 (2018)
6. B. Pratumvinit, T. Srisapoomi, P. Worawattananon, N. Opartkiattikul, W. Jiratchariyakul, T. Kummalue, J. Med. Plants Res. 3, 255-261 (2009)
7. S.C. Mandal, B. Saraswathi, C.K. Kumar, S.M. Lakshmi, B.C. Maiti, Phytother. Res. 14, 457-459 (2000)
8. J.X. Cheng, B.D. Zhang, W.F. Zhu, C.F. Zhang, Y.M. Qin, M. Abe, T. Akihisa, W.Y. Liu, F. Feng, J. Zhang, J. Ethnopharmacol. 248, 112204 (2020)
9. V.A. Yap, B.J. Loong, K.N. Ting, S.H. Loh, K.T. Yong, Y.Y. Low, T.S. Kam, K.H. Lim, Phytochemistry 109, 96-102 (2015)
10. J. Zhang, W.F. Zhu, J. Xu, W. Kitdamrongtham, A. Manosroi, J. Manosroi, H. Tokuda, M. Abe, T. Akihisa, F. Feng, J. Ethnopharmacol. 214, 37-46 (2018)
11. Z.F. Shi, C. Lei, B.W. Yu, H.Y. Wang, A.J. Hou, Chem. Biodivers. 13, 445-450 (2016)
12. R.G. Baker, M.S. Hayden, S. Ghosh, Cell Metab. 13, 11-22 (2011)
13. K. Nishimura, T. Miyase, H. Noguchi, J. Nat. Prod. 62, 1128-1133 (1999)
14. Z.Q. Cao, H.G. Li, Y.J. Tian, F.F. Mu, J.P. Yang, M.L. Wang, N.N. Zhao, Chin. Tradit. Herbal Drugs 16, 386-388 (1985)
15. W. Xu, P. Wang, S.Z. Li, Q.S. Song, Nat. Prod. Res. Dev. 22, 1003-1005 (2010)
16. Y.M. Peng, J.B. Zheng, Y.B. Zhou, J. Li, Acta Pharmacol. Sin. 34, 939-950 (2013)
17. X. Jia, Y. Wu, C. Lei, Y. Yu, J. Li, J. Li, A. Hou, Chin. Chem. Lett. (2019). https://doi.org/10.1016/j.cclet.2019.10.014 |
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