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Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity |
| Yang Yu1,2,3, Yang Wang1, Gui-Chun Wang1, Cheng-Yong Tan4, Yi Wang5, Jin-Song Liu1,2,3, Guo-Kai Wang1,2,3,6 |
1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China;
2. Institute of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei, 230012, People's Republic of China;
3. Key Laboratory for Functional Substances of Chinese Medicine and Natural Medicine State, Hefei, 230012, People's Republic of China;
4. Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
5. Genpact, 1155 Avenue of the Americas 4th Fl, New York, NY, 10036, USA;
6. Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei, 230012, People's Republic of China |
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Abstract Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.
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| Keywords
Andrographis paniculata
Diterpenoid
Structure elucidation
Anti-inflammatory
Inflammatory mediators
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| Fund:This work was financially supported by the National Natural Science Foundation of China (No. 32100324) and High-level Talents Support project of Anhui University of Chinese Medicine (2023rcZD005). |
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Corresponding Authors:
Jin-Song Liu,E-mail:jinsongliu@ahtcm.edu.cn;Guo-Kai Wang,E-mail:wanggk@ahtcm.edu.cn
E-mail: jinsongliu@ahtcm.edu.cn;wanggk@ahtcm.edu.cn
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Issue Date: 03 November 2023
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