| REVIEW |
|
|
|
|
|
On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine |
| Feng-Peng Wang, Ruo-Bing Chao |
| Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China |
|
|
|
|
Abstract This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.
|
| Keywords
Fu Zi
Aconitum carmichaelii
Diterpenoid alkaloid
Mesaconine
|
| Fund:We gratefully acknowledge Professor Chun-Tao Che of the College of Pharmacy, University of Illinois at Chicago for careful review and polish of this manuscript. We also would like to thank Dr. Qi-Feng Chen (Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York. USA) for helpful assistance in writing this manuscript. |
|
Corresponding Authors:
Feng-Peng Wang, Ruo-Bing Chao
E-mail: wfp@scu.edu.cn;rbchao@scu.edu.cn
|
|
Issue Date: 11 March 2021
|
|
|
1. Chinese Pharmacopeia Commission, Chinese pharmacopeia, vol. 1 (China Medical Science Press, Beijing, 2015), pp. 191-193
2. Jiangsu New Medical College, "Zhong-yao da-ci-dian"(the dictionary of Chinese crude drugs) (Shanghai Science and Technology, Beijing, 1977), pp. 1191-1194
3. Institute of Materia Medica, Chinese Academy of medical sciences, Modern researches of Chinese traditional medicines, vol. 1 (Beijing University & China Union Medical University Press, Beijing, 1995), pp. 21-47
4. T. Kosuge, M. Yokota, Chem. Pharm. Bull. 24, 176-178 (1976)
5. C. Kono, M. Shirasaka, H. Hikino, Planta Med. 35, 150-155 (1979)
6. D.H. Chen, X.T. Liang, Acta Pharm. Sin. 17, 792-794 (1984)
7. G.Y. Han, H.Z. Liang, Y.Z. Liao, M.Z. Liu, Acad. J. Sec. Mil. Med. Univ. 12, 10-13 (1991)
8. T.B. Xu, H.F. Zhao, Y.J. Xu, S.X. Xie, Y.S. Si, D. Han, D.M. Xu, Chin. Tradt. Herb Drugs 35, 964-966 (2004)
9. Unpublished works. 1). Institute of Materia Medica, Chinese Academy of Medical Sciences, phase Ⅲ clinical test of dl-demethylconclaurine as a diagnostic agent for early coronary heart disease is carried out; 2). Professor Wei-dong Zhang of the Secondary Military Medical University, one of members in Han's group, communicated with the authors on telephone at 25 July 2020
10. P. He, X.H. Li, Q.H. Chen, J.S. Yang, F.P. Wang, Tetrahedron 70, 4022-4030 (2014)
11. X.X. Liu, Ph. D. Dissertation, Sichuan University, 2006
12. F.P. Wang, R.B. Chao, L.M. Zhou, Unpublished works, which will be definitely reported in due course
13. X.X. Liu, X.X. Jian, X.F. Cai, R.B. Chao, Q.H. Chen, X.L. Wang, F.P. Wang, Chem. Pharm. Bull. 60, 144-149 (2012)
14. F.P. Wang, R.B. Chao, X.X. Jian, X.X. Liu, China Patent CN102146057 B, 7 Nov 2012
15. X.X. Jia, P. Tang, X.X. Liu, R.B. Chao, Q.H. Chen, X.K. She, D.L. Chen, F.P. Wang, Nat. Prod. Commun. 7, 713-720 (2012)
16. Z.T. Zhang, X.X. Jian, J.Y. Ding, H.Y. Deng, R.B. Chao, F.P. Wang, Nat. Prod. Commun. 10, 2075-2084 (2015)
17. Z.W. Hu, X.W. Zhang, F.P. Wang, China Patent CN 107913273 A, 17 Apr 2018
18. F.P. Wang, Z.B. Li, J.S. Yang, B.G. Li, Chem. Pharm. Bull. 10, 453-456 (1999)
19. J.B. Wolffe, J.C. Munch, J. Pharmcol. Exp. Ther. 51, 471-476 (1934)
20. Y.P. Zhou, W.H. Liu, G.Y. Zeng, D.H. Chen, H.Y. Li, W.L. Song, Acta Pharm. Sin. 19, 641-646 (1984)
21. G. Hirohisa, Nippon Yakurigaku Zasshi 52, 496-510 (1956) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
