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Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway |
| Yan-Ni Chen1, Xiao Ding1, Dong-Mei Li1,3, Qing-Yun Lu1,2, Shuai Liu1,2, Ying-Yao Li1,3, Ying-Tong Di1, Xin Fang1, Xiao-Jiang Hao1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan University, Kunming, People's Republic of China |
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Abstract Euphopepluanones F-K (1-4), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, along with eight known diterpenoids (5-12). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1-4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly induced lysosomal biogenesis. In addition, compound 2 could increase the number of LC3 dots, indicating that it could activate the lysosomal-autophagy pathway.
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| Keywords
Euphorbia peplus
Jatrophane
Lysosomal biogenesis activity
Macrocyclic diterpenoid
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| Fund:This research was supported by the National Natural Science Foundation of China under Grant (Numbers 21432010; 31872666; 82073740); National Key R&D Program of China under Grant (Number 2018YFA0900600); Technological leading talent project of Yunnan (2015HA020); Special Fund for Talent Introduction of Kunming Institute of Botany, CAS (to Xin Fang); and Key R&D Program of Yunnan under Grant (2019ZF011-2). |
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Corresponding Authors:
Xin Fang, Xiao-Jiang Hao
E-mail: xinfang@mail.kib.ac.cn;haoxj@mail.kib.ac.cn
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Issue Date: 04 June 2021
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