Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom <i>Psathyrella candolleana</i>

doi:10.1007/s13659-021-00316-x

Natural Products and Bioprospecting

2021, Vol. 11

Issue (4) : 447-452 DOI: 10.1007/s13659-021-00316-x

ORIGINAL ARTICLES

Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Han Wu¹, Hui-Xiang Yang², Zheng-Hui Li², Tao Feng^1,2, Ji-Kai Liu^1,2

1 Anhui Key Laboratory of Modern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China;
2 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

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Abstract Five previously undescribed guanacastane diterpenoids, namely psathyrellins A-E (1-5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1-3 showed antibacterial activity against four strains with MIC values in a range of 16-128 μg/mL.

Keywords Psathyrella candolleana Guanacastane diterpenoids Antibacterial activity

Fund:The work is financially supported by the National Key Research and Development Program of China (Grant No. 2017YFC1704007). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities for the spectra measurements.

Corresponding Authors: Tao Feng, Ji-Kai Liu E-mail: tfeng@mail.scuec.edu.cn;liujikai@mail.scuec.edu.cn

Issue Date: 30 July 2021

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Han Wu,Hui-Xiang Yang,Zheng-Hui Li, et al. Psathyrellins A-E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana[J]. Natural Products and Bioprospecting, 2021, 11(4): 447-452.

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http://npb.kib.ac.cn/EN/10.1007/s13659-021-00316-x OR http://npb.kib.ac.cn/EN/Y2021/V11/I4/447

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