| Short Communication |
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Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05 |
| Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang |
| Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China |
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Abstract Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products (NPs), and despite an ever-increasing number of unknown NPs have been discovered over the past few decades, much of the hidden biosynthetic potential is still in an urgent need to be disclosed. In this research, a chemical investigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05, leading to the isolation of a total of fourteen drimane sesquiterpenoids (1-14), incorporating three new ones, namely ustusols F-H (1-3). Their structures, comprising absolute configurations, were completely authenticated by widespread spectroscopic data, quantum chemical 13C NMR and ECD calculations, and X-ray crystallography experiments. Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release (IC50=25.6 μM).
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| Keywords
Aspergillus calidoustus
Drimane sesquiterpenoids
Structure elucidation
Anti-inflammatory activity
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| Fund:This project was supported financially by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021), the National Natural Science Foundation of China (Nos. 81573316 and 31870326), the Innovative Research Groups of the National Natural Science Foundation of China (No. 81721005), the Fundamental Research Funds for the Central Universities (No. 2020kfyXJJS083), the National Key R&D Program of China (No. 2021YFA0910500), the Research and Development Program of Hubei Province (No. 2020BCA058), and the Chinese Medicine Research Foundation of Health Commission of Hubei Province (No. ZY2021Z019). |
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Corresponding Authors:
Zhengxi Hu,E-mail:hzx616@126.com;Yonghui Zhang,E-mail:zhangyh@mails.tjmu.edu.cn
E-mail: hzx616@126.com;zhangyh@mails.tjmu.edu.cn
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Issue Date: 12 August 2022
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