| Original article |
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Fusagerins A-F, New Alkaloids from the Fungus Fusarium sp. |
| Hao Wen1, Yan Li2, Xingzhong Liu3, Wencai Ye1, Xinsheng Yao1, Yongsheng Che2 |
1. Institute of Traditional Chinese Medicine&Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China;
2. State Key Laboratory of Toxicology&Medical Countermeasures, Beijing Institute of Pharmacology&Toxicology, Beijing 100850, People's Republic of China |
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Abstract Fusagerins A-F(1-6), six new alkaloids including a unique one with the rare a-(N-formyl) carboxamide moiety(1), a hydantoin(imidazolidin-2, 4-dione) derivative(2), and four fungerin analogues(3-6), were isolated from the crude extract of the fungus Fusarium sp. , together with the known compound fungerin(7). Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column. The structures of 1-6 were determined mainly by NMR experiments, and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism(ECD) calculations. Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and weak cytotoxicity against the T24 cells.
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| Keywords
Fusarium sp.
Alkaloids
Structure elucidation
Configuration determination
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| Fund:We gratefully acknowledge financial support from the National Natural Science Foundation of China(81273395) and the National Program of Drug Research and Development(2012ZX09301-003). |
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Issue Date: 11 February 2018
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