| Original Article |
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Anti-inflammatory maistemonine-class alkaloids of Stemona japonica |
| Cheng-Yong Tan1,2, Bao-Bao Shi3, Mei-Fen Bao1, Xiang-Hai Cai1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China;
3. School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan, 430074, People's Republic of China |
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Abstract Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids. Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC50 values of 19.7 and 13.8 μM, respectively, compared to positive control dexamethasone with 11.7 μM. The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.
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| Keywords
Stemona japonica
Stemona alkaloids
Stemajapines A–C
Anti-inflammatory
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| Fund:This project was supported in part by the Xingdian Talent Support Plan and the Bualuang ASEAN Chair Professor Research Grant, Thailand. |
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Corresponding Authors:
Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
E-mail: xhcai@mail.kib.ac.cn
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Issue Date: 18 May 2023
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