| Short Communication |
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Lectin from Crataeva tapia bark exerts antitumor, antiinflammtory and analgesic activities |
| Regina M. S. ARAÚJOa, Antônio F. M. VAZa, Jaciana S. AGUIARb, Luana C. B. B. COELHOa, Patrícia M. G. PAIVAa, Ana M. M. MELOc, Teresinha G. SILVAb, Maria T. S. CORREIAa |
a Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco(UFPE), Avenida Prof. Moraes Rego s/n, 50. 670-420, Recife, PE, Brazil;
b Departamento de Antibióticos, Centro de Ciências Biológicas, Universidade Federal de Pernambuco(UFPE), Avenida Prof. Moraes Rego s/n, 50. 670-420, Recife, PE, Brazil;
c Departamento de Biofísica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco(UFPE), Avenida Prof. Moraes Rego s/n, 50. 670-420, Recife, PE, Brazil |
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Abstract Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice. The antiinflammatory and analgesic properties were investigated in models of inflammation and nociception. The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response. The lectin presents low toxicity with a LD50 of 2, 500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth. The lectin also promoted significant reduction(35.4%) in the number of neutrophil migration induced by carrageenan. Concerning its analgesic property, the lectin inhibits abdominal contractions induced by acetic acid. The current results revealed a lectin with significant antitumoral, anti-inflammatory and antinociceptive activities. Further investigations to unveil the exact mechanisms are needed.
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| Keywords
Crataeva tapia
lectin
antitumoral
anti-inflammatory
antinociceptive
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| Fund:This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq). The authors also wish to thank Ronaldo Celerino da Silva and Sílvia Rafaelli Ramos for their valuable technical assistance. |
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Issue Date: 24 November 2017
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