Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from <i>Eucalyptus robusta</i>: absolute structure and cytotoxicity

doi:10.1007/s13659-011-0021-9

Natural Products and Bioprospecting

2011, Vol. 1

Issue (2) : 101-103 DOI: 10.1007/s13659-011-0021-9

Short Communication

Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Li-Yan PENG, Juan HE, Gang XU, Xing-De WU, Liao-Bin DONG, Xiu GAO, Xiao CHENG, Jia SU, Yan LI, Qin-Shi ZHAO

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

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Abstract Euglobal-IIIa(1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC₅₀ values of 15.7, 15.5, 17.6, 14.3, and 21.8 μM, respectively.

Keywords Eucalyptus robusta acylphloroglucinol-sesquiterpene absolute structure cytotoxicity

Fund:This work was financially supported by the National Natural Science Foundation of China(No. 90813004 and No. 2009312311024), the 973 Program(No. 2009CB522300), and the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ05).

Issue Date: 24 November 2017

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	Li-Yan PENG
	Juan HE
	Gang XU
	Xing-De WU
	Liao-Bin DONG
	Xiu GAO
	Xiao CHENG
	Jia SU
	Yan LI
	Qin-Shi ZHAO

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Li-Yan PENG,Juan HE,Gang XU, et al. Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity[J]. Natural Products and Bioprospecting, 2011, 1(2): 101-103.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0021-9 OR http://npb.kib.ac.cn/EN/Y2011/V1/I2/101

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