Traditional Uses and Pharmacologically Active Constituents of <i>Dendrobium</i> Plants for Dermatological Disorders: A Review

doi:10.1007/s13659-021-00305-0

Natural Products and Bioprospecting

2021, Vol. 11

Issue (5) : 465-487 DOI: 10.1007/s13659-021-00305-0

REVIEWS

Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review

Yue-Hu Wang

Key Laboratory of Economic Plants and Biotechnology, The Yunnan Key Laboratory for Wild Plant Resources, and Bio-Innovation Center of DR PLANT, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, People's Republic of China

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Abstract Dendrobium Sw. is one of the largest genera in the orchidaceous family and includes 900-2000 species. Among them, more than 80 Dendrobium species have been reported in China. However, there are only six Dendrobium species, namely, D. bigibbum var. superbum (syn. D. phalaenopsis), D. chrysanthum, D. fi mbriatum, D. loddigesii, D. nobile, and D. officinale (syn. D. candidum), listed in the New Inventory of Existing Cosmetic Ingredients in China Launched. Artificial planting of Dendrobium species has been a great success in China. To better utilize Dendrobium resources for medicinal and cosmetic purposes, we summarize their traditional uses and pharmacologically active compounds for treating dermatological disorders in this review. "Orchidaceae", "Dendrobium", "traditional use", "ethnobotany", "dermatological disorder", and "skin disease" were used as search terms to screen the literature. Cited references were collected between 1970 and 2020 from the Web of Science, China National Knowledge Internet (CNKI), SciFinder, Google Scholar, and Chinese books. From the search, it was found that there are 22 Dendrobium species with traditional uses in dermatological disorders, and 131 compounds from Dendrobium plants have been reported to possess anti-inflammatory, antimicrobial, antioxidant, antiaging, anti-psoriasis, and tyrosinase-inhibitory activities, implying that Dendrobium plants are important resources for the discovery of active compounds and the development of new drugs and cosmetics. D. crepidatum, D. denneanum, D. loddigesii, D. nobile, and D. officinale have been extensively studied. More research on other Dendrobium species is needed. The major active compounds found in Dendrobium species are phenanthrenes, alkaloids, flavonoids, phenylpropanoids, and lignans. Several compounds, such as loddigesiinol A, (S)-5-methoxy-2,4,7,9-tetrahydroxy-9,10-dihydrophenanthrene, (S)-4-methoxy-2,5,7,9-tetrahydroxy-9,10-dihydrophenanthrene, 2,5-dihydroxy-4-methoxy-phenanthrene 2-O-β-D-glucopyranoside, (9R)-1,2,5,9-tetrahydroxy-9,10-dihydrophenanthrene 5-O-β-D-glucopyranoside, (+)-homocrepidine A, and vicenin 2, have significant anti-inflammatory activities and inhibit nitric oxide (NO) production with IC₅₀ values less than 5 μM, and these compounds are worthy of further study.

Keywords Orchidaceae Dendrobium Traditional uses Dermatological disorders Anti-inflammatory

Fund:This research was funded by the Beijing DR PLANT Biotechnology Co., Ltd. and the Second Tibetan Plateau Scientific Expedition and Research (STEP) Program of Ministry of Science and Technology of the People's Republic of China (2019QZKK0502).

Corresponding Authors: Yue-Hu Wang E-mail: wangyuehu@mail.kib.ac.cn

Issue Date: 27 September 2021

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Yue-Hu Wang. Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review[J]. Natural Products and Bioprospecting, 2021, 11(5): 465-487.

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http://npb.kib.ac.cn/EN/10.1007/s13659-021-00305-0 OR http://npb.kib.ac.cn/EN/Y2021/V11/I5/465

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