Chemical components of <i>Dendrobium crepidatum</i> and their neurite outgrowth enhancing activities

doi:10.1007/s13659-012-0103-3

Natural Products and Bioprospecting

2013, Vol. 3

Issue (2) : 70-73 DOI: 10.1007/s13659-012-0103-3

Short Communication

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

Cheng-Bo LI^a, Cong WANG^a,b, Wei-Wei FAN^a,b, Fa-Wu DONG^a,b, Feng-Qing XU^a,b, Qin-Li WAN^a, Huai-Rong LUO^a, Yu-Qing LIU^a, Jiang-Miao HU^a, Jun ZHOU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract 15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 μM.

Keywords Orchidaceae Dendrobium crepidatum bibenzyl neurite outgrowth enhancing activity

Fund:This work was financially supported by National Natural and Science Foundations of China (No. 30800090), "Xi-BuZhi-Guang" project (2009-2012) from Chinese Academy of Science and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ012). The authors are grateful to the members of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, for all the spectral measurements.

Issue Date: 11 February 2018

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	Cheng-Bo LI
	Cong WANG
	Wei-Wei FAN
	Fa-Wu DONG
	Feng-Qing XU
	Qin-Li WAN
	Huai-Rong LUO
	Yu-Qing LIU
	Jiang-Miao HU
	Jun ZHOU

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Cheng-Bo LI,Cong WANG,Wei-Wei FAN, et al. Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities[J]. Natural Products and Bioprospecting, 2013, 3(2): 70-73.

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http://npb.kib.ac.cn/EN/10.1007/s13659-012-0103-3 OR http://npb.kib.ac.cn/EN/Y2013/V3/I2/70

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