| ORIGINAL ARTICLES |
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The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines |
| Yin-Zhong Fan, Chun Tian, Shun-Yao Tong, Qing Liu, Fan Xu, Bao-Bao Shi, Hong-Lian Ai, Ji-Kai Liu |
| School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan, 430074, People's Republic of China |
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Abstract A series of terpenoids (1–17), comprising six new compounds designated bipolariterpenes A-F (1–6) and eleven recognized compounds (7–17), were isolated from the wheat culture of the potato endophytic fungus Bipolaris eleusines. Their structures and stereochemistry were clarified by HRESIMS, NMR, DP4+probability analyses, and computations for electronic circular dichroism (ECD). All compounds are made up of six meroterpenoids, four sesterterpenes and seven sesquiterpenes. Among them, four sesterterpenes (4, 5, 10, 11) were investigated for their antifungal, antibacterial and cytotoxic properties, and six meroterpenoids (1–3, 7–9) were evaluated for their antifungal properties. The compounds 7, 9, and 10 had substantial antifungal activity against Epidermophyton floccosum at a concentration of 100 μM. No antibacterial and cytotoxic activities were observed.
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| Keywords
Endophytic fungus
Bipolaris eleusines
Terpenoids
Isolation and structure elucidation
Antifungal activity
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| Fund:This work was financially supported by the National Natural Science Foundation of China (32000011, 82204239), Hubei Provincial Natural Science Foundation of China (2022CFB462), the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2022-KF03), the Fundamental Research Funds for the Central Universities, South-Central MinZu University (CZY23024). |
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Corresponding Authors:
Bao-Bao Shi,E-mail:shibb0505@163.com;Hong-Lian Ai,E-mail:aihonglian@mail.scuec.edu.cn;Ji-Kai Liu,E-mail:liujikai@mail.scuec.edu.cn
E-mail: shibb0505@163.com;aihonglian@mail.scuec.edu.cn;liujikai@mail.scuec.edu.cn
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Issue Date: 26 December 2023
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