Three new pyrrole alkaloids from the endophytic fungus <i>Albifimbria viridis</i>

doi:10.1007/s13659-022-00327-2

Natural Products and Bioprospecting

2022, Vol. 12

Issue (1) : 1-5 DOI: 10.1007/s13659-022-00327-2

ORIGINAL ARTICLES

Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

Pan-Pan Wei, Jia-Cheng Ji, Xu-Jun Ma, Zheng-Hui Li, Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

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Abstract Three new pyrrole alkaloids albifipyrrols A-C (1-3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC₅₀ value 16.16 μM.

Keywords Pyrrole alkaloids Coptis chinensis Endophytic fungus Albifimbria viridis Immunosuppressive activity

Fund:National Natural Science Foundation of China (31870513), Zheng-Hui Li, National Aerospace Science Foundation of China (32000011), Hong-Lian Ai.

Corresponding Authors: Hong-Lian Ai, Xin-Xiang Lei, Ji-Kai Liu E-mail: aihonglian@mail.scuec.edu.cn;xxlei@mail.scuec.edu.cn;liujikai@mail.scuec.edu.cn

Issue Date: 12 March 2022

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Pan-Pan Wei,Jia-Cheng Ji,Xu-Jun Ma, et al. Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis[J]. Natural Products and Bioprospecting, 2022, 12(1): 1-5.

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http://npb.kib.ac.cn/EN/10.1007/s13659-022-00327-2 OR http://npb.kib.ac.cn/EN/Y2022/V12/I1/1

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