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Five new limonoids isolated from Walsura robusta |
| Li Hou1,2,4, Cui-Xuan Mei1,3, Chun-Mao Yuan1,5, Gui-Hua Tang1, Duo-Zhi Chen1, Qing Zhao2, Hong-Ping He1,2, Ming-Ming Cao1, Xiao-Jiang Hao1,5,6,7 |
1. State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
2. School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China;
3. University of Chinese Academy of Sciences, Beijing, 100049, China;
4. Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area, Changsha, 410205, China;
5. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China;
6. Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Beijing, 100730, China;
7. Yunnan Characteristic Plant Extraction Laboratory, Kunming, 650106, China |
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Abstract Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.
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| Keywords
Limonoids
Tetranortriterpenoids
Walsura robusta
Cytotoxicity
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| Fund:This research was supported financially by grants from the National Natural Science Foundation of China (U1812403 to X.-J. Hao and 22177050 to M. Cao), Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001), Foundation of Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM202103, China), and Youth Innovation Promotion Association CAS to M. Cao (2022-2026). |
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Corresponding Authors:
Hong-Ping He,E-mail:hehongping@yahoo.com;Ming-Ming Cao,E-mail:caomingming@mail.kib.ac.cn;Xiao-Jiang Hao,E-mail:haoxj@mail.kib.ac.cn
E-mail: hehongping@yahoo.com;caomingming@mail.kib.ac.cn;haoxj@mail.kib.ac.cn
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Issue Date: 18 May 2023
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