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Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri |
| Guang-Xing Yu1,2, Jing Wu1, Bao-Bao Shi1, Mei-Fen Bao1, Xiang-Hai Cai1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100039, People's Republic of China |
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Abstract Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.
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| Keywords
Cephalotaxus oliveri
Cephalotaxaceae
Alkaloid
Enantiomer
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| Fund:This project was funded in part by the National Natural Science Foundation of China (No. 31872677). |
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Corresponding Authors:
Xiang-Hai Cai,E-mail:xhcai@mail.kib.ac.cn
E-mail: xhcai@mail.kib.ac.cn
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Issue Date: 12 August 2022
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