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Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers |
| Ghodsi Mohammadi Ziarani, Negar Jamasbi, Fatemeh Mohajer |
| Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P. O. Box 1993893973, Tehran, Iran |
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Abstract Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies.
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| Keywords
Polyhydroxylated pyrrolizidine alkaloids
Alexine
Natural products
Alexa leiopetala
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| Fund:The authors thank the Research Council of Alzahra University for its support. |
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Corresponding Authors:
Ghodsi Mohammadi Ziarani
E-mail: gmohammadi@alzahra.ac.ir
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Issue Date: 12 March 2022
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