| ORIGINAL ARTICLES |
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Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis |
| Zong-Qing Huo, Qian Zhao, Wen-Tao Zhu, Xiao-Jiang Hao, Yu Zhang |
| State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China |
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Abstract Four new monoterpenoid indole alkaloids, bousmekines A-D (1-4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4 μM.
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| Keywords
Bousigonia
B. angustifolia
B. mekongensis
Monoterpenoid indole alkaloids
Bousmekines A-E
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| Fund:This work was financially supported by Yunnan Applied Basic Research Projects (2018FA049) and Top Young Talent of the Ten Thousand Talents Program of Yunnan (to Y. Zhang). |
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Corresponding Authors:
Yu Zhang
E-mail: zhangyu@mail.kib.ac.cn
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Issue Date: 07 April 2021
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