| Short Communication |
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Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| Ahmed H. Elbanna1,2, Xinhui Kou1, Dilip V. Prajapati1, Surasree Rakshit1, Rebecca A. Butcher1 |
1. Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA;
2. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt |
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Abstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides.
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| Keywords
Euglena gracilis
Euglenatide
Natural products
Polyketide
Nonribosomal peptide
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| Fund:This work was supported by a grant from the National Institutes of Health (R35 GM144076 to R.A.B.). |
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Corresponding Authors:
Rebecca A. BUTCHER,E-mail:butcher@chem.ufl.edu
E-mail: butcher@chem.ufl.edu
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Issue Date: 15 February 2025
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