The alkynyl-containing compounds from mushrooms and their biological activities

doi:10.1007/s13659-023-00416-w

Natural Products and Bioprospecting

2023, Vol. 13

Issue (6) : 50-50 DOI: 10.1007/s13659-023-00416-w

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The alkynyl-containing compounds from mushrooms and their biological activities

Ji-shuang Qi¹, Yingce Duan¹, Zhao-chen Li², Jin-ming Gao², Jianzhao Qi^1,2, Chengwei Liu¹

1. Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin, 150040, China;
2. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China

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Abstract Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses. Despite their relatively low abundance, naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity. Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms. Moreover, it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.

Keywords Mushroom Alkynyl compounds Bioactivity Chemical structures

Fund:This work was supported by the National Natural Science Foundation of China (No. 32370069 and U22A20369), the Fundamental Research Funds for the Central Universities (2572023AW40), the Natural Science Foundation of Heilongjiang Province of China (No. LH2023C035), and the Key R&D Projects in Shaanxi Province of China (No.2023-YBSF-164).

Corresponding Authors: Jianzhao Qi,E-mail:qjz@nwafu.edu.cn;Chengwei Liu,E-mail:liuchw@nefu.edu.cn E-mail: qjz@nwafu.edu.cn;liuchw@nefu.edu.cn

Issue Date: 26 December 2023

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Ji-shuang Qi,Yingce Duan,Zhao-chen Li, et al. The alkynyl-containing compounds from mushrooms and their biological activities[J]. Natural Products and Bioprospecting, 2023, 13(6): 50-50.

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http://npb.kib.ac.cn/EN/10.1007/s13659-023-00416-w OR http://npb.kib.ac.cn/EN/Y2023/V13/I6/50

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