| Original article |
|
|
|
|
|
Effects of Traditional Chinese Medicinal Plants on Antiinsulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells |
| Jun-Zeng Ma1, Li-Xin Yang1,2, Xiao-Ling Shen3, Ji-Huan Qin3, Li-Lan Deng4, Selena Ahmed2,5, Hong-Xi Xu6, Da-Yuan Xue2, Jiang-Xia Ye4, Gang Xu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing 100086, China;
3. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, People's Republic of China;
4. Southwest Forestry University, Kunming 650224, People's Republic of China;
5. Sustainable Food and Bioenergy Systems Program, Department of Health and Human Development, Montana State University, Bozeman, MT 59717, USA;
6. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China |
|
|
|
|
Abstract Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone(DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.
|
| Keywords
Traditional medicinal plants
Diabetes
Anti-insulin resistance bioactivity
DXMS-induced insulin resistant HepG2 cells
|
| Fund:The work was financially supported by China National Major Projects(2009ZX09103-436) and 973 Program(2011CB915503) of Science and Technology of P. R. China, the reservation-talent project of Yunnan Province(2009CI073), the foundation of study abroad returnees from Ministry of Personnel for financial support(Ms. Li-Xin Yang), and the foundations from CAS(Dr. Gang Xu). |
|
Issue Date: 11 February 2018
|
|
|
1. G.I. Bell, K.S. Polonsky, Nature 414, 788-791 (2001)
2. P. Zimmet, K.G. Alberti, J. Shaw, Nature 414, 782-787 (2001)
3. M. Brownlee, Nature 414, 813-820 (2001)
4. International Diabetes Federation, Diabetes Atlas, 5th edn. (International Diabetes Federation, Brussels, 2012)
5. A.J. Krentz, C.J. Bailey, Drugs 65, 385-411 (2005)
6. B.J. Goldstein, D. Müller-wieland, Type 2 Diabetes:Principles and Practice, 2nd edn. (Informa, New York, 2008)
7. J.B. Won, J.Y. Ma, C.T. Ma, Arch. Pharm. Res. 33, 619-625 (2010)
8. S.Z. Liu, Y.X. Deng, B. Chen, X.J. Zhang, Q.Z. Shi, X.M. Qiu, J. Ethnopharmacol. 145, 490-498 (2013)
9. K. He, X.G. Li, X. Chen, X.L. Ye, J. Huang, Y.N. Jin, P.P. Li, Y.F. Deng, Q. Jin, Q. Shi, H.J. Shu, J. Ethnopharmacol. 137, 1135-1142 (2011)
10. F.L. Guo, Shanghai J. Tradit. Chin. Med 3, 14-16 (2000)
11. M.L. Chao, D.J. Zou, Y.F. Zhang, Y.H. Chen, M. Wang, H. Wu, G. Ning, W.Q. Wang, Endocrine 36, 268-274 (2009)
12. F. Firenzuoli, L. Gori, Evid-Based Compl. Altern. Med. 4, 37-40 (2007)
13. Y.J. Kang, Exp. Biol. Med. 233, 1059-1065 (2008)
14. J. Van der Greef, H. Van Wietmarschen, J. Schro/n, M. Wang, T. Hankemeier, G.W. Xu, Planta Med. 76, 2036-2047 (2010)
15. S. Costantini, G.D. Bernardo, M. Cammarota, G. Castello, G. Colonna, Gene 518, 335-345 (2013)
16. L.J. Dong, Y.Z. Jin, L. Shi, G.M. Song, J. Third Mil. Med. Univ. 34, 671-673 (2012)
17. R.Z. Yu, China J. Tradit. Chin. Med. Pharm. 9, 57 (1991)
18. H.Y. Zhang, Beijing J. Tradit. Chin. Med. 3, 49-51 (1998)
19. Y.Q. Zhang, G.Z. He, Q. Han, X.M. Kong, Y. Li, P.A. Zeng, Y. Zhang, Q.G. Zhang, X.S. Zhou, Chin. J. Basic. Med. Tradit. Chin. Med. 10, 45-47 (2004)
20. C.Y. Hu, S.H. Gao, Chin. J. Inf. TCM 12, 93-94 (2005)
21. W.Y. Kang, Y.L. Song, L. Zhang, Med. Chem. Res. 20, 809-816 (2011)
22. O.D. Can, Y. O ztürk, N. O ztürk, G. Sagratini, M. Ricciutelli, S. Vittori, F. Maggi, Fitoterapia 82, 576-584 (2011)
23. J.X. Wang, Chin. Med. Mod. Dist. Edu. China 7, 93-94 (2009)
24. Y.H. Zhang, Z.X. Zheng, Y.H. Liu, J.Y. Teng, R.X. Zhang, X.H. Liu, C.Y. Xue, Chin. J. Clin. Rehabil. 10, 111-113 (2006)
25. A.M. Xu, H.B. Wang, L.C. Hoo, R.G. Sweeney, P.M. Vanhoutte, Y. Wang, D.H. Wu, W.J. Chu, G.W. Qin, K.S.L. Lam, Endocrinology 150, 625-633 (2009)
26. M.E. Xu, S.Z. Xiao, Y.H. Sun, Y. Ouyang, X.X. Zheng, Acta Pharmacol. Sin. 27, 229-236 (2006)
27. P. Shen, M.H. Liu, T.Y. Ng, Y.H. Chan, E.L. Yong, J. Nutr. 136, 899-905 (2006)
28. Y. Wu, J.P. Ouyang, K. Wu, Y. Wang, Y.F. Zhou, C.Y. Wen, Acta Pharmacol. Sin. 26, 345-352 (2005)
29. M. Liu, K. Wu, X.Q. Mao, Y. Wu, J.P. Ouyang, J. Ethnopharmacol. 127, 32-37 (2010)
30. X. Zhang, Y.F. Zhao, M.H. Zhang, X.Y. Pang, J. Xu, C.Y. Kang, M. Li, C.H. Zhang, Z.G. Zhang, Y.F. Zhang, X.Y. Li, G. Ning, L.P. Zhao, PLoS One 7, 1-12 (2012)
31. X. Ma, T. Egawa, H. Kimura, K. Karaike, S. Masuda, N. Iwanaka, T. Hayashi, Metabolism 59, 1619-1627 (2010)
32. X. Xia, J.H. Yan, Y.F. Shen, K.X. Tang, J. Yin, Y.H. Zhang, D.J. Yang, H. Liang, J.P. Ye, J.P. Weng, PLoS One 6, 1-10 (2011)
33. S. Jiang, P.G. Du, L.P. An, G.X. Yuan, Z.W. Sun, Int. J. Biol. Macromol. 55, 118-122 (2013)
34. C. Guo, R. Li, N. Zheng, L.Y. Xu, T. Liang, Q.L. He, Int. Immunopharmacol. 16, 93-99 (2013)
35. M. Zhang, M. Chen, H.Q. Zhang, S. Sun, B. Xia, F.H. Wu, Fitoterapia 80, 475-477 (2009)
36. A.N.B. Singab, H.A. El-Beshbishy, M. Yonekawa, T. Nomura, T.J. Fukai, Ethnopharmacology 100, 333-338 (2005)
37. K. Wu, T. Liang, X.Q. Duan, L.Y. Xu, K.F. Zhang, R. Li, Food Chem. Toxicol. 60, 341-347 (2013)
38. W.C. Chen, S. Hayakawa, T. Yamamoto, H.C. Su, I.M. Liu, J.T. Cheng, Planta Med. 70, 113-116 (2004)
39. O.H. Lee, D.H. Seo, C.S. Park, Y.C. Kim, BioFactors 36, 459-467 (2010)
40. F.L. Xiong, X.H. Sun, L. Gan, X.L. Yang, H.B. Xu, Eur. J. Pharmacol. 529, 1-7 (2006)
41. Q. Li, X.L. Ye, H. Zeng, X. Chen, X.G. Li, J. Chin. Med. Mat. 35, 475-479 (2012)
42. X.B. Yang, Z.M. Huang, W.B. Cao, H.Y. Chen, W.H. Tian, J.H. Wang, Chin. J. Exp. Tradit. Med. Form. 8, 24-26 (2002)
43. C.H. Lau, C.M. Chan, Y.W. Chan, K.M. Lau, T.W. Lau, F.C. Lam, C.T. Che, P.C. Leung, K.P. Fung, Y.Y. Ho, C.B.S. Lau, Phytother. Res. 22, 1384-1388 (2008)
44. D.Z. Li, D.Y. Peng, X.X. Xu, R. Zhang, Chin. Arch. Tradit. Chin. Med. 26, 2717-2718 (2008)
45. X.X. Xu, D.Z. Li, D.Y. Peng, R. Zhang, Chin. J. Exp. Tradit. Med. Form. 17, 232-234 (2011)
46. D.Y. Kwon, D.S. Kim, H.J. Yang, S. Park, J. Ethnopharmacol. 135, 455-462 (2011)
47. E.K. Ahn, J.A. Lee, D.W. Seo, S.S. Hong, J.S. Oh, Biol. Pharm. Bull. 35, 643-649 (2012)
48. U. Unachukwu, S. Ahmed, A. Kavalier, J. Lyles, E.J. Kennelly, Food Sci. 75(6), C541-C548 (2010)
49. H.Y. Chen, X.G. Li, X.L. Ye, Y.N. Jin, J. Huang, J.F. Wu, China J. Chin. Mat. Med. 37, 1771-1774 (2012)
50. Y. Jiang, E.Y. Ahn, S.H. Ryu, D.K. Kim, J.S. Park, H.J. Yoon, S. You, B.J. Lee, D.S. Lee, J.H. Jung, BMC Cancer 4, 70 (2004) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
