Three New Humulane Sesquiterpenes from Cultures of the Fungus <i>Antrodiella albocinnamomea</i>

doi:10.1007/s13659-014-0032-4

Natural Products and Bioprospecting

2014, Vol. 4

Issue (4) : 207-211 DOI: 10.1007/s13659-014-0032-4

Original article

Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea

Zi-Ming Chen¹, Qiong-Ying Fan², Xia Yin¹, Xiao-Yan Yang¹, Zheng-Hui Li¹, Tao Feng¹, Ji-Kai Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Heilongtan, Kunming 650201, Yunnan, People's Republic of China;
2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China;
2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China

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Abstract Three new humulane-type sesquiterpenes, antrodols A-C(1-3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A-C(1-3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A(1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.

Keywords Antrodiella albocinnamomea Humulane-type sesquiterpenes Protein tyrosine phosphatase inhibitory activity

Fund:This project was financially supported by National Natural Science Foundation of China(U1132607, 81373289, 81102346) and Youth Innovation Promotion Association of CAS(2011312D11019).

Issue Date: 11 February 2018

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Zi-Ming Chen,Qiong-Ying Fan,Xia Yin, et al. Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea[J]. Natural Products and Bioprospecting, 2014, 4(4): 207-211.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0032-4 OR http://npb.kib.ac.cn/EN/Y2014/V4/I4/207

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