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Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea |
Zi-Ming Chen1, Qiong-Ying Fan2, Xia Yin1, Xiao-Yan Yang1, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Heilongtan, Kunming 650201, Yunnan, People's Republic of China; 2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China; 2. College of Life Science, Hebei Normal University, Shijiazhuang 050024, People's Republic of China |
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Abstract Three new humulane-type sesquiterpenes, antrodols A-C(1-3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A-C(1-3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A(1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases(PTPs):MEG2 and PTP1Bc.
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Keywords
Antrodiella albocinnamomea
Humulane-type sesquiterpenes
Protein tyrosine phosphatase inhibitory activity
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Fund:This project was financially supported by National Natural Science Foundation of China(U1132607, 81373289, 81102346) and Youth Innovation Promotion Association of CAS(2011312D11019). |
Issue Date: 11 February 2018
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