Nine New Farnesylphenols from the Basidiomycete <i>Albatrellus Caeruleoporus</i>

doi:10.1007/s13659-014-0015-5

Natural Products and Bioprospecting

2014, Vol. 4

Issue (2) : 119-128 DOI: 10.1007/s13659-014-0015-5

Original article

Nine New Farnesylphenols from the Basidiomycete Albatrellus Caeruleoporus

Liang-Yan Liu^1,2, Zheng-Hui Li¹, Gang-Qiang Wang¹, Kun Wei¹, Ze-Jun Dong¹, Tao Feng¹, Gen-Tao Li¹, Yan Li¹, Ji-Kai Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2. University of the Chinese Academy of Sciences, Beijing 100049, China

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Abstract Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives(1-8) and one grifolin analogue(9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as(S)-17-hydroxy-18, 20-ene-neogrifolin(1),(S)-18, 19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10, 22-ene-neogrifolin(3),(9S, 10R)-6, 10-epoxy-9-hydroxyneo grifolin(4),(9S, 10R)-6, 9-epoxy-10-hydroxyneogrifolin(5),(-)-13, 14-dihydroxyneogrifolin(6), albatrelin G(7), albatrelin H(8), and one grifolin analogue,(S)-10-hydroxygrifolin(9), grifolin(10), neogrifolin(11), and albatrellin(12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

Keywords Albatrellus caeruleoporus Mushroom Polyporaceae Farnesylphenols

Fund:This project was supported by the National Natural Sciences Foundation of China(U1132607).

Issue Date: 11 February 2018

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	Liang-Yan Liu
	Zheng-Hui Li
	Gang-Qiang Wang
	Kun Wei
	Ze-Jun Dong
	Tao Feng
	Gen-Tao Li
	Yan Li
	Ji-Kai Liu

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Liang-Yan Liu,Zheng-Hui Li,Gang-Qiang Wang, et al. Nine New Farnesylphenols from the Basidiomycete Albatrellus Caeruleoporus[J]. Natural Products and Bioprospecting, 2014, 4(2): 119-128.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0015-5 OR http://npb.kib.ac.cn/EN/Y2014/V4/I2/119

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