| ORIGINAL ARTICLES |
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Artemyrianins A-G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells |
| Shuang Tang1,2, Yun-Bao Ma1, Chang-An Geng1, Cheng Shen1,2, Tian-Ze Li1, Xue-Mei Zhang1, Li-Hua Su1,2, Zhen Gao1,2, Jing Hu1, Ji-Jun Chen1,2 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract Four new sesquiterpenoids, artemyrianins A-D (1-4), and three new norlignans, artemyrianins E-G (5-7), together with five known compounds (8-12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC50 values ranging from 33.3 to 145.2 μM.
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| Keywords
Artemisia myriantha
Artemyrianins A-G
Sesquiterpenoids
Norlignans
Cytotoxicity
HepG2 cells
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| Fund:This work was financially supported by the Yunnan Wanren Project (YNWR-KJLJ-2019-002), the Program of Yunling Scholarship, the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province, and the Youth Innovation Promotion Association, CAS (2013252). |
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Corresponding Authors:
Ji-Jun Chen
E-mail: chenjj@mail.kib.ac.cn
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Issue Date: 19 August 2020
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