Two New Eudesmane Sesquiterpenoids from the Flowers of <i>Chrysanthemum indicum</i>

doi:10.1007/s13659-019-0199-9

Natural Products and Bioprospecting

2019, Vol. 9

Issue (2) : 145-148 DOI: 10.1007/s13659-019-0199-9

ORIGINAL ARTICLE

Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum

Jun-Li Yang, Lei-Lei Liu, Yan-Ping Shi

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China

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Abstract The flowers of Chrysanthemum indicum,i.e.Ye-ju-hua recorded in the Chinese Pharmacopoeia,has been widely used in China as an important heat-clearing and detoxifying herb for the treatment of inflammation,headache,and vertigo.A phytochemical investigation of this herb has led to the isolation of two new eudesmane sesquiterpenoids,7-epi-eudesm-4(15),11(13)-diene-1β,3β-diol (1) and 7-epi-1β-hydroxy-β-eudesmol (2).The molecular structures of these new sesquiterpenoids were established based on the comprehensive spectroscopic analyses,including NMR,MS,and IR,and comparing with the literatures.

Keywords Chrysanthemum indicum Sesquiterpenoids Eudesmane

Fund:This work was financially supported by National Natural Science Foundation of China (Nos.81673325,81711540311,and 21705156),the International Partnership Program of CAS (No.153631KYSB20160004),Gansu Province Key International S&T Cooperation Project (No.18YF1WA127),and CAS Pioneer Hundred Talents Prog

Corresponding Authors: Yan-Ping Shi E-mail: shiyp@licp.cas.cn

Issue Date: 04 April 2019

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Jun-Li Yang,Lei-Lei Liu,Yan-Ping Shi. Two New Eudesmane Sesquiterpenoids from the Flowers of Chrysanthemum indicum[J]. Natural Products and Bioprospecting, 2019, 9(2): 145-148.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-0199-9 OR http://npb.kib.ac.cn/EN/Y2019/V9/I2/145

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