| Regular Article |
|
|
|
|
|
Four new diterpenoids from Isodon eriocalyx var. laxiflora |
| Wei-Guang WANGa,b, Xue DUa, Xiao-Nian LIa, Bing-Chao YANa,b, Min ZHOUa,b, Hai-Yan WUa,b, Rui ZHANa,b, Ke DONGa, Jian-Xin PUa, Han-Dong SUNa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China |
|
|
|
|
Abstract Four new diterpenoids, laxiflorins S-V (1-4), bearing four different types, and one known compound, laxiflorin O (5), were isolated from Isodon eriocalyx var. laxiflora. Compound 1 was the first example of ent-kauranoids bearing a unique C24 carbon framework and compound 4 was the first example of 3,4-seco-ent-abietane diterpenoids from the Isodon genus. Their structures were determined by spectroscopic methods (UV, IR, MS, NMR).
|
| Keywords
Isodon eriocalyx var. laxiflora
laxiflorins
diterpenoid
ent-kaurane
ent-abietane
|
| Fund:The authors are grateful to Prof. Xi-Wen Li of the Kunming Institute of Botany, Chinese Academy of Sciences, for the identification of the plant. This project was supported financially by the National Natural Science Foundation of China (No. 81172939), the West Light Foundation of the Chinese Academy of Sciences (J.X. Pu), the Major State Basic Research Development Program of China (No. 2009CB522300), the reservation talent project of Yunnan Province (2011CI043 to J.X. Pu), the Science and Technology Program of Yunnan Province (Nos. 2008IF010), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project (No. KSCX2-EW-J-24 to J.X. Pu). |
|
Issue Date: 11 February 2018
|
|
|
| [1] |
Li, J. W.; Vederas, J. C. Science 2009, 325, 161-165.
|
| [2] |
Dandapani, S.; Marcaurelle, L. A. Nat. Chem. Biol. 2010, 6, 861-863.
|
| [3] |
Medina-Franco, J. Drug Des. 2012, 1, e105.
|
| [4] |
Sun, H. D.; Huang, S. X.; Han, Q. B. Nat. Prod. Rep. 2006, 23, 673-698.
|
| [5] |
Zhan, R.; Du, X.; Su, J.; Li, X. N.; Wang, W. G.; Liang, C. Q.; Yang, J. H.; Li, Y.; Pu, J. X.; Sun, H. D. Nat. Prod. Bioprospect. 2011, 1, 116-120.
|
| [6] |
Niu, X. M.; Li, S. H.; Li, M. L.; Zhao, Q. S.; Mei, S. X.; Na, Z.; Wang, S. J.; Lin, Z. W.; Sun, H. D. Planta Med. 2002, 68(6), 528-533.
|
| [7] |
Wang, W. G.; Wu, H. Y.; Du, X.; Yan, J. M.; Li, Y.; Pu, J. X.; Sun, H. D. Chin. J. Chem. 2012, 30, 1226-1230.
|
| [8] |
Niu, X. M.; Li, S. H.; Mei, S. X.; Na, Z.; Zhao, Q. S.; Lin, Z. W.; Sun, H. D. J. Nat. Prod. 2002, 65, 1892-1896.
|
| [9] |
Sun, H. D.; Lin, Z. W.; Niu, F. D.; Shen, P. Q.; Pan, L. T.; Lin, L. Z.; Cordell, G. A. Phytochemistry 1995, 38, 1451-1455.
|
| [10] |
Niu, X.; Li, S.; Zhao, Q.; Lin, Z.; Sun, H.; Lu, Y.; Wang, C.; Zheng, Q. Tetrahedron Lett. 2002, 43, 661-664.
|
| [11] |
Niu, X.; Li, S.; Zhao, Q.; Mei, S.; Lin, Z.; Sun, H.; Lu, Y.; Wang, C.; Zheng, Q. Helv. Chim. Acta 2003, 86, 299-306.
|
| [12] |
Wang, W. G.; Li, X. N.; Du, X.; Dong, K.; Zhao, W.; Wu, H. Y.; Kong, L. M.; Li, Y.; Pu, J. X.; Sun, H. D., Tetrahedron Lett. 2012, 53, 2777-2781.
|
| [13] |
Wang, W. G.; Li, X. N.; Du, X.; Wu, H. Y.; Liu, X.; Su, J.; Li, Y.; Pu, J. X.; Sun, H. D. J. Nat. Prod. 2012, 75, 1102-1107.
|
| [14] |
Wang, W. G.; Du, X.; Li, X. N.; Wu, H. Y.; Liu, X.; Shang, S. Z.; Zhan, R.; Liang, C. Q.; Kong, L. M.; Li, Y.; Pu, J. X.; Sun, H. D. Org. Lett. 2012, 14, 302-305.
|
| [15] |
Niu, X. M.; Li, S. H.; Li, M. L.; Zhao, Q. S.; Mei, S. X.; Na, Z.; Wang, S. J.; Lin, Z. W.; Sun, H. D. Planta Med. 2002, 68, 528-533.
|
| [16] |
Shen, P.; Sun, H.; Lin, Z. Yunnan Zhiwu Yanjiu 1986, 8, 163-166.
|
| [17] |
Fujita, E.; Fujita, T.; Shibuya, M. Chem. Commun. 1967, 148-149.
|
| [18] |
Flack, H.; Bernardinelli, G. Acta Crystallogr., Sect. A 1999, 55, 908-915.
|
| [19] |
Flack, H. D. Acta Crystallogr., Sect. A 1983, 39, 876-881.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
