| ORIGINAL ARTICLES |
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Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus |
| Qi-Xiu Hai1,2, Kun Hu2, Su-Ping Chen2, Yang-Yang Fu2, Xiao-Nian Li2, Han-Dong Sun2, Hong-Ping He1, Pema-Tenzin Puno2 |
1. College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China;
2. Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China |
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Abstract Three new ent-kaurane diterpenoids, silvaticusins A-C (1-3), along with a new ent-kaurane dimer silvaticusin D (4) were isolated from the aerial parts of Isodon silvaticus. The structures of these new compounds were established mainly by comprehensive analysis of their NMR and MS data. The absolute configuration of compounds 1 and 4 were determined using a single-crystal X-ray diffraction and computational methods, respectively. Compounds 2 and 3 were found to exhibit remarkable cytotoxic effects against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, and SW-480), with IC50 values spanning from 1.27±0.08 to 7.52±0.33 μM.
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| Keywords
Isodon silvaticus
ent-Kaurane diterpenoid
ent-Kaurane dimer
Cyclobutane moiety
Cytotoxicity
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| Fund:This work was financially supported by the National Science Fund for Distinguished Young Scholars (82325047), Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), NSFC-Joint Foundation of Yunnan Province (U2002221), and Youth Innovation Promotion Association CAS (2023409). |
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Corresponding Authors:
Hong-Ping He,E-mail:95431111@qq.com;Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
E-mail: 95431111@qq.com;punopematenzin@mail.kib.ac.cn
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Issue Date: 14 October 2024
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