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Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1 |
| Wei-Ye Wu1, Xun Wei1, Qiong Liao2, Yi-Fan Fu1, Lei-Ming Wu1, Lei Li1, Shu-Qi Wu1, Qing-Ren Lu1, Fang-Yu Yuan1, Dong Huang1, Zhang-Hua Sun3, Tao Yuan4, Gui-Hua Tang1 |
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China;
2. Laboratory Animal Center, Sun Yat-sen University, Guangzhou, 510006, China;
3. Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan, 512005, China;
4. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China |
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Abstract A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC50 value of 4.24±0.13 μM, more than the positive control drug (12.99±0.13 μM).
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| Keywords
Endophytic fungus
Penicillium canescens
Polyketides
Alkaloids
Cytotoxic activity
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| Fund:This work was supported by the Science and Technology Program of Guangzhou, China (No. 2024B03J1322), the Science and Technology Planning Project of Guangdong Province, China (No. 2023A1111120025), the National Natural Science Foundation of China (Nos. 82404454 and 22407144), and the Guangdong Basic and Applied Basic Research Foundation, China (No. 2021B1515140062). |
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Issue Date: 18 June 2025
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