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Recent advances in the application of [2+2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products |
| Song-Yu Hou, Bing-Chao Yan, Han-Dong Sun, Pema-Tenzin Puno |
| Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China |
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Abstract Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural frameworks. The [2+2] cycloaddition is unequivocally the primary and most commonly used method for synthesizing cyclobutanes. In this review, we have summarized the application of the [2+2] cycloaddition with different reaction mechanisms in the chemical synthesis of selected cyclobutane-containing natural products over the past decade.
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| Keywords
[2+2] Cycloaddition
Total synthesis
Natural products
Cyclobutane
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| Fund:This work was financially supported by the National Science Fund for Distinguished Young Scholars (82325047), Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), NSFC-Joint Foundation of Yunnan Province (U2002221). |
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Corresponding Authors:
Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn
E-mail: punopematenzin@mail.kib.ac.cn
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Issue Date: 14 October 2024
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