| ORIGINAL ARTICLES |
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Irlactane and Tremulane Sesquiterpenes from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102 |
| He-Ping Chen1, Xu Ji2, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1 |
1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China |
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Abstract A new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A-N (2-15), and a known irlactane-type sesquiterpenoid, were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102. The structures of all the isolates were characterized by extensive spectroscopic methods, including 1D and 2D NMR and MS spectroscopic analysis. The absolute configurations of irlactin K and the known compound conocenol B (20) were established by single-crystal X-ray diffraction analysis. The vasorelaxant effects of irlactin K (1), irpexolactins A (2), C (4), K (12), and irlactam (22) were evaluated.
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| Keywords
Irpex lacteus
Meruliaceae
Irlactane
Tremulane
Sesquiterpene
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| Fund:This work was financially supported by National Natural Science Foundation of China (Nos.81903512, 21961142008). We thank Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central University for Nationalities for MS and NMR spectra tests. |
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Corresponding Authors:
Ji-Kai Liu
E-mail: jkliu@mail.kib.ac.cn,liujikai@mail.scuec.edu.cn
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Issue Date: 06 May 2020
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