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Chemical investigation on the cultures of the fungus Xylaria carpophila |
| Xia YINa,b, Tao FENGa, Zheng-Hui LIa, Jia SUa, Yan LIa, Ning-Hua TANa, Ji-Kai LIUa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China |
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Abstract A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-L-Phe-L-Pro-L-Leu-D-Ile-L-Val)(1), five new sesquiterpenes, named as xylcarpins A-E(2-6), and another known compound(7). The structures were determined by extensive NMR and MS spectroscopic analysis. The absolute configuration of 1 was established by use of Marfey's method and ROESY spectroscopic data. All compounds were tested for their cytotoxicities against five human cancer cell lines. Compound 7 showed week inhibitory activity.
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| Keywords
Xylaria carpophila
sesquiterpenes
cyclopeptide
cytotoxicity
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| Fund:This project was supported by the National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Sciences Foundation of China(30830113), and MOST(2009ZX09501-029). |
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Issue Date: 24 November 2017
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