Clausenlanins A and B, Two Leucine-Rich Cyclic Nonapeptides from <i>Clausena lansium</i>

doi:10.1007/s13659-017-0133-y

Natural Products and Bioprospecting

2017, Vol. 7

Issue (4) : 307-313 DOI: 10.1007/s13659-017-0133-y

Original article

Clausenlanins A and B, Two Leucine-Rich Cyclic Nonapeptides from Clausena lansium

Shai-Ping Hu^1,2, Wei-Wu Song^2,3, Si-Meng Zhao², Ning-Hua Tan^1,2

1. School of Traditional Chinese Pharmacy and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, Jiangsu, People's Republic of China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
3. School of Chemistry & Chemical Engineeing, Zhoukou Normal University, Zhoukou 466001, Henan, People's Republic of China

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Abstract Two new cyclic nonapeptides, named clausenlanins A (1) and B (2), were isolated from the roots and rhizomes of Clausena lansium. Their structures were elucidated as cyclo-(Gly^{1^{-L-Leu^{2^{-L-Ile³-L-Leu^{4^{-L-Leu^{5^{-L-Leu^{6^{-L-Leu^{7^{-L-Leu^{8^{- L-Leu^{9^{) (1) and cyclo-(Gly^{1^{-L-Leu^{2^{-L-Val³-L-Leu^{4^{-L-Leu^{5^{-L-Leu^{6^{-L-Leu^{7^{-L-Leu^{8^{-L-Leu^{9^{) (2) respectively on the basis of extensive spectroscopic analysis, particularly 2D NMR spectra taken at the temperature of 338 or 303 K and MS.}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}

Keywords Clausena lansium Cyclopeptides Clausenlanin A Clausenlanin B

Fund:This work was supported by the Program for Jiangsu Province Innovative Research Team, the National Basic Research Program of China (2013CB127505), the National Natural Science Foundation of China (31470428), the Project of State Key Laboratory of Natural Medicines (SKLNMZZCX201614), and the Foundation of High-level Talent Introduction of China Pharmaceutical University.

Issue Date: 07 February 2018

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Shai-Ping Hu,Wei-Wu Song,Si-Meng Zhao, et al. Clausenlanins A and B, Two Leucine-Rich Cyclic Nonapeptides from Clausena lansium[J]. Natural Products and Bioprospecting, 2017, 7(4): 307-313.

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http://npb.kib.ac.cn/EN/10.1007/s13659-017-0133-y OR http://npb.kib.ac.cn/EN/Y2017/V7/I4/307

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