Cyclopeptides from <i>Amanita exitialis</i>

doi:10.1007/s13659-011-0013-9

Natural Products and Bioprospecting

2011, Vol. 1

Issue (1) : 52-56 DOI: 10.1007/s13659-011-0013-9

Regular Article

Cyclopeptides from Amanita exitialis

Jing-Hua XUE, Ping WU, Yu-Lang CHI, Liang-Xiong XU, Xiao-Yi WEI

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China

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Abstract A new cyclic nonapeptide, amanexitide(1), along with the known cyclopeptides, α-and β-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.

Keywords Amanita Amanita exitialis cyclopeptides amanexitide

Fund:This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No. KSCX2-YW-N-036).

Issue Date: 10 November 2017

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	Xiao-Yi WEI

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Jing-Hua XUE,Ping WU,Yu-Lang CHI, et al. Cyclopeptides from Amanita exitialis[J]. Natural Products and Bioprospecting, 2011, 1(1): 52-56.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0013-9 OR http://npb.kib.ac.cn/EN/Y2011/V1/I1/52

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