Anti-hepatitis B virus active secoiridoids from <i>Swertia kouitchensis</i>

doi:10.1007/s13659-011-0009-5

Natural Products and Bioprospecting

2011, Vol. 1

Issue (1) : 48-51 DOI: 10.1007/s13659-011-0009-5

Regular Article

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Kang HE^a,b, Yun-Bao MA^a, Chang-An GENG^a, Xue-Mei ZHANG^a, Tuan-Wu CAO^a,b, Fu-Qiang JIANG^a,b, Ji-Jun CHEN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

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Abstract Three new secoiridoids, swertiakoulactone(1) and swertiakosides A and B(2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus(HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion(IC₅₀=1.10 mM, SI=4.39) and HBV DNA replication(IC₅₀=1.16 mM, SI=4.12).

Keywords Swertia kouitchensis anti-HBV activity swertiakoulactone swertiakoside A swertiakoside B

Fund:This work was financially supported by the National Natural Sciences Foundation of China for Distinguished Young Scholar(No. 81025023). The authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for the measurements of all spectra.

Issue Date: 10 November 2017

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Kang HE,Yun-Bao MA,Chang-An GENG, et al. Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis[J]. Natural Products and Bioprospecting, 2011, 1(1): 48-51.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0009-5 OR http://npb.kib.ac.cn/EN/Y2011/V1/I1/48

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