Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: <i>Swertia mileensis</i>

doi:10.1007/s13659-013-0059-y

Natural Products and Bioprospecting

2013, Vol. 3

Issue (5) : 243-249 DOI: 10.1007/s13659-013-0059-y

Regular Article

Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

Chang-An GENG, Xue-Mei ZHANG, Yun-Bao MA, Xiao-Yan HUANG, Ji-Jun CHEN

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

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Abstract Eleven new secoiridoid aglycones involving unusual C₉-skeleton:swerimilegenins A-F (1-6); bis-C₉-skeleton:swerimilegenin G (7); and C₁₀-skeleton:swerimilegenins H-K (8-11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis. Their structures were determined by extensive spectroscopic data and X-ray diffraction. Biogenetically, swerimilegenin A (1) belonged to 10-nor-secoiridoid, and swerimilegenins B-F (2-6) were 1-nor-secoiridoids. Erythrocentaurin (12) and gentiogenal (15) showed moderate anti-HBV activity on HepG 2.2.15 cell line in vitro.

Keywords Swertia mileensis swerimilegenins secoiridoid aglycones anti-HBV activity

Fund:This work was funded by the National Natural Science Foundation of China and Yunnan Province (U0832603), the National Science Foundation of China for Distinguished Young Scholars (81025023), the West Light Foundation of the Chinese Academy of Sciences, the International Foundation for Science (No. F/5202-1), and the Youth Innovation Promotion Association, CAS.

Issue Date: 11 February 2018

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Chang-An GENG,Xue-Mei ZHANG,Yun-Bao MA, et al. Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis[J]. Natural Products and Bioprospecting, 2013, 3(5): 243-249.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0059-y OR http://npb.kib.ac.cn/EN/Y2013/V3/I5/243

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