Toxicity Assessment of Cadinene Sesquiterpenes from <i>Eupatorium adenophorum</i> in Mice

doi:10.1007/s13659-014-0050-2

Natural Products and Bioprospecting

2015, Vol. 5

Issue (1) : 29-36 DOI: 10.1007/s13659-014-0050-2

Original article

Toxicity Assessment of Cadinene Sesquiterpenes from Eupatorium adenophorum in Mice

Can-Bin Ouyang¹, Xiao-Man Liu¹, Qi Liu², Jie Bai¹, Hou-Yong Li¹, Yuan Li¹, Qiu-Xia Wang¹, Dong-Dong Yan¹, Lian-Gang Mao¹, Aocheng Cao¹, Mei-Xia Guo¹

1. Department of Pesticides, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Ministry of Agriculture, and State Key Laboratory for Biology of Plant Diseases and Insect Pests, Beijing 100193, People's Republic of China;
2. National Engineering Laboratory for Crop Efficient Water Use and Disaster Mitigation, and Key Laboratory of Dryland Agriculture, Ministry of Agriculture, Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, People's Republic of China

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Abstract This study evaluated toxic efficacy of Eupatorium adenophorum extracts, against the Kunming mice. In acute study, we firstly tested median lethal dose(LD₅₀) in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA), 9-oxo-agerophorone(OA) and 9-oxo-10, 11-dehydro-agerophorone(ODA) from Eupatorium adenophorum(Ea). DAOA(215-4640 mg/kg BW, given orally) showed lowest LD₅₀ at 926 mg/kg BW for male mice in contrast with OA(1470 mg/kg BW) and ODA(1470 mg/kg BW). In sub-acute study, repeated doses(75-300 mg/kg BW, for 7 days) of DAOA/OA increased blood parameters, liver and spleen index in dose dependent relationship, along with decrease in thymus index. The blood biochemical and histopathological examination showed that DAOA/OA dose 300 mg/kg BW significantly causes pathological changes of hepatic lobules and hepatocytes, which are consistent with cholestasis and hepatic injury. 75 mg/kg dose of DAOA/OA was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters. Cadinene sesquiterpenes guarantee low risk to environment as a type of low toxic botanical components, which may find potential application in biopesticides development field.

Keywords Eupatorium adenophorum Sesquiterpenes Histopathology Environmental toxicity Biopesticide

Issue Date: 11 February 2018

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	Can-Bin Ouyang
	Xiao-Man Liu
	Qi Liu
	Jie Bai
	Hou-Yong Li
	Yuan Li
	Qiu-Xia Wang
	Dong-Dong Yan
	Lian-Gang Mao
	Aocheng Cao
	Mei-Xia Guo

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Can-Bin Ouyang,Xiao-Man Liu,Qi Liu, et al. Toxicity Assessment of Cadinene Sesquiterpenes from Eupatorium adenophorum in Mice[J]. Natural Products and Bioprospecting, 2015, 5(1): 29-36.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0050-2 OR http://npb.kib.ac.cn/EN/Y2015/V5/I1/29

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