Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

doi:10.1007/s13659-019-00220-5

Natural Products and Bioprospecting

2019, Vol. 9

Issue (5) : 311-328 DOI: 10.1007/s13659-019-00220-5

REVIEW

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Rufin Marie Kouipou Toghueo

Antimicrobial and Biocontrol Agents Unit(AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon

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Abstract Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

Keywords Anti-leishmanial Anti-inflammatory Endophytes Bioactive metabolites

Fund:Rufin Marie Kouipou Toghueo is a postdoctoral researcher at the Drug Discovery Unit, University of Dundee. This integrated programme is developed by the Drug Discovery Unit with the support of the Wellcome Centre for Anti-Infective Research as a special programme for leadership research, capacity building, and training in drug discovery against tropical diseases.

Corresponding Authors: Rufin Marie Kouipou Toghueo E-mail: toghueo.rufin@yahoo.fr

Issue Date: 30 October 2019

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Rufin Marie Kouipou Toghueo. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review[J]. Natural Products and Bioprospecting, 2019, 9(5): 311-328.

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http://npb.kib.ac.cn/EN/10.1007/s13659-019-00220-5 OR http://npb.kib.ac.cn/EN/Y2019/V9/I5/311

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