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Synthesis and Cytotoxicities of Royleanone Derivatives |
| Cheng-Ji Li1,3, Fan Xia1,3, Rong Wu2, Hong-Sheng Tan2, Hong-Xi Xu2, Gang Xu1, Hong-Bo Qin1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
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| Keywords
Royleanones
Cytotoxicity
para benzoquinone
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| Fund:The work was financially supported by the foundations from NSFC (81373291) to Dr. G. Xu, NSFC (21372229) to Dr. H. B. Qin, and from Foundation of Kunming Institute of Botany (KIB2017007) to Dr. G. Xu. |
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Corresponding Authors:
Hong-Xi Xu, Gang Xu, Hong-Bo Qin
E-mail: xuhongxi88@gmail.com;xugang008@mail.kib.ac.cn;qinhongbo@mail.kib.ac.cn
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Issue Date: 21 November 2018
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