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A New Epi-neoverrucosane-type Diterpenoid from the Liverwort Pleurozia subinflata in Borneo |
| Takashi Kamada1,2, Mary Lyn Johanis2, Shean-Yeaw Ng2, Chin-Soon Phan2, Monica Suleiman2, Charles S. Vairappan2 |
1 Department of Materials and Life Science, Faculty of Science and Technology, Shizuoka Institute of Science and Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka 437-8555, Japan;
2 Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia |
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Abstract New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia's liverwort Pleurozia subinfl ata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.
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| Keywords
Epi-neoverrucosane
Diterpenoid
Pleurozia subinfl ata
Liverwort
Borneo
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| Fund:This research was financially supported by SaBC Grant [No. GL0070] and UMS Grant [SBK0258-SG-2016]. |
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Corresponding Authors:
Takashi Kamada
E-mail: takashi.kamada800@gmail.com
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Issue Date: 29 February 2020
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