| Regular Article |
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Three new triterpenoids from Rubia schumanniana |
| Bin KUANGa,b, Jing HANa,b, Guang-Zhi ZENGa, Xiao-Qiang CHENa, Wen-Jun HEa, Ning-Hua TANa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Three new triterpenoids, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyl-12-en-28-oic-acid(1), 3β-hydroxy-olean-30-p-E-hydroxycinnamoyl-12-en-28-oic-acid(2) and 3β, 6α-dihydroxy-urs-14-en-12-one(3), together with seven known triterpenoids, were isolated from the roots of Rubia schumanniana. Their structures were established by means of spectroscopic analysis. All compounds were evaluated for cytotoxic activity, and compounds 2-6 showed cytotoxicity with the IC50 values of 10.75~18.87 μg/mL.
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| Keywords
Rubia schumanniana
triterpenoid
cytotoxicity
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| Fund:This work was supported by the National Natural Science Foundation of China(U1032602, 91013002, 30725048), the National New Drug Innovation Major Project of China(2011ZX09307-002-02), and the National Basic Reaearch Program of China(2009 CB522300). |
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Issue Date: 11 February 2018
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