Natural Products and Bioprospecting    2021, Vol. 11 Issue (3) : 243-306     DOI: 10.1007/s13659-021-00303-2
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Cembranoids of Soft Corals: Recent Updates and Their Biological Activities
Marsya Yonna Nurrachma, Deamon Sakaraga, Ahmad Yogi Nugraha, Siti Irma Rahmawati, Asep Bayu, Linda Sukmarini, Akhirta Atikana, Anggia Prasetyoputri, Fauzia Izzati, Mega Ferdina Warsito, Masteria Yunovilsa Putra
Research Center for Biotechnology, Indonesian Institute of Sciences(LIPI), Jalan Raya Jakarta-Bogor KM. 46, Cibinong, Bogor, West Java, Indonesia
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Abstract  Soft corals are well-known as excellent sources of marine-derived natural products. Among them, members of the genera Sarcophyton, Sinularia, and Lobophytum are especially attractive targets for marine natural product research. In this review, we reported the marine-derived natural products called cembranoids isolated from soft corals, including the genera Sarcophyton, Sinularia, and Lobophytum. Here, we reviewed 72 reports published between 2016 and 2020, comprising 360 compounds, of which 260 are new compounds and 100 are previously known compounds with newly recognized activities. The novelty of the organic molecules and their relevant biological activities, delivered by the year of publication, are presented. Among the genera presented in this report, Sarcophyton spp. produce the most cembranoid diterpenes; thus, they are considered as the most important soft corals for marine natural product research. Cembranoids display diverse biological activities, including anti-cancer, anti-bacterial, and anti-inflammatory. As cembranoids have been credited with a broad range of biological activities, they present a huge potential for the development of various drugs with potential health and ecological benefits.
Keywords Cembranoids      Diterpene      Soft corals      Sarcophyton      Sinularia      Lobophytum      Anti-bacterial      Anti-cancer      Anti-inflammatory     
Corresponding Authors: Asep Bayu, Masteria Yunovilsa Putra     E-mail: asepbayu@yahoo.co.id,asep046@lipi.go.id;mast001@lipi.go.id,masteria.yunovilsa@gmail.com
Issue Date: 04 June 2021
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Marsya Yonna Nurrachma
Deamon Sakaraga
Ahmad Yogi Nugraha
Siti Irma Rahmawati
Asep Bayu
Linda Sukmarini
Akhirta Atikana
Anggia Prasetyoputri
Fauzia Izzati
Mega Ferdina Warsito
Masteria Yunovilsa Putra
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Marsya Yonna Nurrachma,Deamon Sakaraga,Ahmad Yogi Nugraha, et al. Cembranoids of Soft Corals: Recent Updates and Their Biological Activities[J]. Natural Products and Bioprospecting, 2021, 11(3): 243-306.
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http://npb.kib.ac.cn/EN/10.1007/s13659-021-00303-2     OR     http://npb.kib.ac.cn/EN/Y2021/V11/I3/243
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