| Original article |
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Synthesis of L-Ascorbic Acid Lactone Derivatives |
| Li-Dong Shao1,3, Ya-Nan Wu1,3, Jun Xu1,3, Juan He1, Yu Zhao1, Li-Yan Peng1, Yan Li1, Yu-Rong Yang1, Cheng-Feng Xia1, Qin-Shi Zhao2 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract A small focused library which comprised of L-AA lactone derivatives was built with a facile method. This reported method was optimized by modifying the acidity of the solvent. As a result, 12 L-AA lactones were synthesized. Among these lactones, lactones 8-12 were new compounds. The cytotoxicity of these synthetic compounds were investigated.
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| Keywords
L-Ascorbic acid lactone
Cytotoxicity
Focused library
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| Fund:This work was financially supported by the National Natural Science Foundation of China(No. U0932602) and the National Basic Research Program of China(973 Program No. 2011CB915503). All authors do not have any financial/commercial conflicts of interest. |
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Issue Date: 11 February 2018
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