| Regular Article |
|
|
|
|
|
Six novel steroids from culture of basidiomycete Polyporus ellisii |
| Shuang WANGa,b, Ling ZHANGa, Liang-Yan LIUa,b, Ze-Jun DONGa, Zheng-Hui LIa, Ji-Kai LIUa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China |
|
|
|
|
Abstract Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β, 9α, 15α-trihydroxy-(22E, 24R)-10(5→4)-abeo-ergosta-6, 8(14), 22-trien-5-one(1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β, 6β-epoxy-3β, 7α, 9α-trihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-15-one(2), 5β, 6β-epoxy-3β, 7α-dihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-15-one(3), 5α, 6α-epoxy-3β, 9α, 15α-trihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-7-one(4), 15α-acetoxy-(22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one(5), 15β-methoxy-(22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one(6), along with four known ergosterols(7-10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines.
|
| Keywords
ergosterol
Polyporus ellisii
basidiomycete
cytotoxicity
|
| Fund:This work was financially supported by National Basic Research Program of China(973 Program, 2009CB522300), the National Natural Science Foundation of China(30830113, U1132607). |
|
Issue Date: 11 February 2018
|
|
|
| [1] |
Gao, J. M.; Zhang, A. L.; Yao, H. Y. Zhongguo Zhongyao Zazhi 2003, 28, 953-945.
|
| [2] |
Gao, J. M.; Hu, L.; Dong, Z. J.; Liu, J. K. Lipids 2001, 36, 521-527.
|
| [3] |
Liu, J. K. Heterocycles 2002, 57, 157-167.
|
| [4] |
Wang, F. Z.; Fang, Y. C.; Zhang, M.; Gu, Q. Q.; Zhu, W. M. Steroids 2008, 73, 19-26.
|
| [5] |
Taro, A.; Makoto, T.; Atsushi, N. J. Nat. Prod. 2007, 70, 1731-1740.
|
| [6] |
Ponce, M. A.; Ramirez, J. A.; Erra-Balsells, R. Photochem. Photobiol. Sci. 2002, 1, 749-756.
|
| [7] |
Adler, J. H.;Young, M.; Nes, W, R. Lipids 1977, 12, 364-366.
|
| [8] |
Wright J. L. C.; McInnes, A. G.; Shimizu, S. Can. J. Chem. 1978, 56, 1898-1903.
|
| [9] |
John Wiley & Sons:Chichester, West Sussex, England, 2002, p 232.
|
| [10] |
Tayyab. A. M.; Lee, Y. M.; Jung, J. H. J. Nat. Prod. 2006, 69, 131-134.
|
| [11] |
Bridgeman, J. E.; Cherry, P. C.; Woodgate, P. D. J. Chem. Soc. 1970, 250-257.
|
| [12] |
Schulte, K. E.; Buecker, G.; Fachmann, H. Tetrahedron Lett. 1968, 46, 4763-4764.
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
