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Vibralactone Biogenesis-Associated Analogues from Submerged Cultures of the Fungus Boreostereum vibrans |
| He-Ping Chen1, Meng-Yuan Jiang2, Zhen-Zhu Zhao1, Tao Feng1, Zheng-Hui Li1, Ji-Kai Liu1 |
1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming 650504, People's Republic of China |
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Abstract A scale-up fermentation of the fungus Boreostereum vibrans facilitated the isolation of six new vibralactone biogenesisassociated analogues, namely vibralactamide A (1), vibralactone T (2), 13-O-lactyl vibralactone (3), 10-O-acetyl vibralactone G (4), (11R,12R)-and (11S,12R)-vibradiol (5, 6). Their structures were established via extensive spectroscopic analyses, specific optical rotation comparison, and Snatzke's method. The biosynthetic pathway for vibralactamide A was postulated. The absolute configuration of vibralactone B was revised by single crystal X-ray diffraction analysis. This work puts the divergent vibralactone biosynthesis pathway one step further and expands the structural diversity of vibralactoneassociated compounds.
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| Keywords
Basidiomycete
Boreostereum vibrans
Vibralactone
Structure revision
Snatzke's method
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Corresponding Authors:
Ji-Kai Liu
E-mail: jkliu@mail.kib.ac.cn
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Issue Date: 27 February 2018
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